CBET Contract Research Solutions (C²RS) is built for companies ready to move their ideas forward. Backed by an expert team and industry-relevant technologies, we bring the skills and tools to deliver results across the biomanufacturing continuum. From advancing novel therapies to optimizing established processes, our collaborative approach accelerates research timelines and drives innovation.
“CBET performed crucial testing to evaluate the performance of our equipment and provided meaningful data across various applications for which our technology may be used. From the initial consultation to the final deliverables, their team demonstrated professionalism, expertise, and dedication that exceeded our expectations.
Differentiated Research Capabilities
Your project deserves more than standard support. It deserves a partner equipped to deliver progress with efficiency and confidence. At CBET Contract Research Solutions (C²RS), you will access capabilities that span the biomanufacturing continuum:
- Process development – optimizing upstream and downstream workflows
- Cell line development – designing expression systems for consistent performance
- Mammalian cell culture – cultivating reproducible growth in bioreactor systems
- Gene therapy (AAV & lentivirus) – evaluating vectors and generating process insights
- Microbial fermentation – innovating with batch, continuous, and perfusion systems
- Downstream processing – maximizing yield and product integrity
- Protein purification – refining biomolecules for research and therapeutic goals
- Biologics analysis – characterizing quality, safety, and function
Distinctive Advantages
- Broad expertise – applying scientific, research, and industry knowledge to each project
- Tailored solutions – designing approaches that deliver your specific goals
- Seamless support – guiding projects from initiation through reporting
- Collaborative insight – leveraging diverse perspectives to deliver efficient outcomes
- Pace alignment – working at the speed your project demands
- Proven results – delivering trusted data that inform next-phase plans
Enabling Innovation with Industry-Relevant Equipment
At the Stack Family Center for Biopharmaceutical Education and Training, CBET Contract Research Solutions (C²RS) connects your project to the same technologies used across the industry. Our labs feature cell culture and microbial fermentation systems for producing antibodies, proteins, enzymes, and more, along with tools for cell and gene therapy development. Both single-use and traditional platforms are available to match your project’s needs. From upstream to downstream, you will access the equipment that powers discovery forward.
Biomanufacturing Capabilities
CBET Contract Research Solutions (C²RS) offers a spectrum of technologies that enable clients to move seamlessly from concept to data. Core capabilities span production, processing, and analytics:
- Adenovirus and lentivirus production
- Cloning and cell line selection
- Human, mammalian, and insect cell culture
- Media optimization
- Microbial fermentation
- Perfusion and scale-up studies
- Cell lysis and clarification
- Lyophilization
- Protein purification
- Tangential flow filtration
- Assay development
- Automated microscopy
- Endotoxin removal/testing
- PCR / RT-PCR / qPCR
- UHPLC-DAD and FLD
- Western blotting / ELISAs
Borisenok Family Foundation Upstream Lab
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DASBox® Mini Bioreactor
Mini-bioreactor system with 2 × 4 reusable 150 mL vessels, compatible with both cell culture and microbial applications. Enables smooth scale-up or scale-down with industry-standard design for reproducibility and scalability.
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BioFlo® 320 Bioreactor
Bench-top bioreactor with 5 L autoclavable glass vessels, supporting both cell culture and microbial scale-up or scale-down processes. Suitable for batch, fed-batch, continuous, or perfusion runs, with robust design, advanced sensors, ethernet connectivity, and enhanced software control.
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iCELLis™ Nano Bioreactor
Automated, single-use fixed-bed bioreactor optimized for anchorage-dependent cells. Features a unique waterfall oxygenation system for efficient CO₂ stripping, enabling high cell density and productivity.
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WAVE™ 25 Rocker Bioreactor
Single-use rocker bioreactor with integrated temperature sensors and load cells for cultures up to 25 L. Rocking motion provides efficient mixing and aeration with convenient handling and control.
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Xcellerex™ XDR 10 Bioreactor
Single-use stirred-tank bioreactor handling 4.5–10 L working volumes. Ideal for process development, small-scale production, and troubleshooting, with a low-shear impeller ensuring gentle yet efficient mixing.
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XCell® ATF 2 Perfusion System
Single-use perfusion system with hollow-fiber filtration technology to retain cells while continuously clarifying bioreactor contents. Clarification enhances productivity and cell density, while the system also supports scale-up or scale-down.
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IN Cell Analyzer 2500HS
High-content widefield imaging system optimized for speed, throughput, and image quality. Features deconvolution, 3D imaging, and a live-cell module for long-term imaging experiments.
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Vi-CELL BLU Cell Analyzer
Automated cell viability analyzer with rapid optical counting, expanded sample capacity, and reduced test volumes. Delivers accurate, reproducible results with improved comparability across instruments.
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EVOS™ M5000 Imaging System
Fluorescence imaging system with a high-resolution CMOS camera and up to four fluorescence channels, one of which can be used for transmitted light. Captures publication-ready images in seconds with a user-friendly interface and minimal manual handling.
Downstream Lab
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Optima XPN-100 Ultracentrifuge
Ultracentrifuge with titanium rotors reaching up to 100,000 rpm, enabling separation by differential sedimentation. Provides rapid and efficient separation with advanced biosafety features for a secure and productive workflow.
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PandaPLUS 2000 Homogenizer
High-pressure homogenizer operating up to 1,500 bar with flow rates to 5,000 L/h, with a maximum capacity of 2,000 bar. Delivers ultra-fine droplet and particle size reduction for nanoparticles, dispersions, emulsions, and cell disruption, with applications across food, pharmaceuticals, biotechnology, cosmetics, and chemicals.
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High-Speed Continuous Centrifuge
Semi-continuous industrial centrifuge designed for separation of solids from fermentation suspensions. Capable of separating and removing two liquids simultaneously, supporting large-scale extraction of viruses and bacteria.
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ÄKTA™ flux System
Semi-automated tangential flow and crossflow filtration system for concentration, diafiltration, cell harvest, and clarification. Supports cassettes, hollow fiber cartridges, and membrane adsorbers for low working and hold-up volumes across a wide range of concentration factors.
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ÄKTA pure™ 25 M System
Versatile chromatography system for biomolecule purification including proteins, peptides, and nucleic acids, with flow rates up to 25 mL/min. Supports SEC, AEC, CEC, Protein A/G, HIC, and IMAC methods, with UNICORN software for data acquisition and analysis.
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ÄKTA start™ System
Entry-level chromatography system for lab-scale protein purification. Operates stand-alone via the touchscreen display or with a computer loaded with UNICORN Start software, ideal for academic labs and new users.
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Vanquish Flex UHPLC
Duo UHPLC system equipped with Chromeleon software for biomolecular analysis, operating up to 1000 enables high-resolution biomolecule analysis with precision, speed, and reproducibility. Ideal for characterizing proteins, peptides, nucleic acids, and other complex biological products.
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NanoDrop™ OneC Spectrophotometer
Microvolume UV-Vis spectrophotometer requiring only 1–2 µL samples. Provides full-spectrum analysis for DNA, RNA, protein quantification, and microbial cell density measurements.
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CFX96™ Touch Real-Time PCR System
Six-channel real-time PCR detection system combining advanced optics with precise temperature control. Enables sensitive, reliable singleplex or multiplex genetic analyses with CFX Maestro software for data collection and analysis.
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Synergy H1 Plate Reader
Configurable multi-mode microplate reader with monochromator and filter-based optics for flexibility and sensitivity. Hybrid technology supports a wide range of assays including cell-based, biomarker, kinetic, nucleotide, and protein applications.
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ChemiDoc™ MP Imaging System
Full-featured platform for imaging and quantifying nucleic acids and proteins in gels and western blots. Supports multiplex fluorescent blotting, chemiluminescence, stain-free imaging, and general gel documentation.
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Endosafe® nexgen-PTS™
A rapid, handheld spectrophotometer designed to deliver real-time quantitative endotoxin analysis at point of sample collection in as little as 15 minutes.
Supporting Equipment
CBET’s additional equipment assets provide the infrastructure needed to maintain research quality, safety, and reproducibility for each project.
- Bead mill homogenizer
- Biosafety cabinets
- Cell counters
- DNA gel electrophoresis systems
- Drying Ovens
- Inverted microscopes with cameras
- Lab dishwasher
- Large-scale autoclaves
- Liquid nitrogen dewars
- Lyophilizers
- Mammalian cell culture incubators
- Microbiological incubators
- Minicentrifuges
- Protein blot modules
- Refrigerated centrifuges
- Shaking bacterial incubators
- Ultralow -80 freezers
- Western blot systems
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