Pharmaceutical Sciences

EDUCATION

• Ph.D. University of Michigan, Pharmacology
• B.S. Clarkson University, Bio-molecular Science and Chemistry

COURSES TAUGHT AT ACPHS

• Pathophysiology
• PTP&M
• Pharmacology

RESEARCH INTERESTS

• My research focuses on interactions between mu and delta opioid receptors in the production of tolerance and dependence. Using computational modeling of the mu and delta opioid receptor, I designed, synthesized, and characterized bifunctional tetra- and pentapeptides to produce ligands displaying both mu-agonism and delta-antagonism.

SELECTED PUBLICATIONS

• Anand, J.C., Purington, L.C., Pogozheva, I.D., Traynor, J.R., Mosberg, H.I. "Modulation of opioid receptor ligand affinity and efficacy using active and inactive state receptor models." Chemical Biology Drug Design, 80:763-770, 2012.
• Purington, L.C., Sobczyk-Kojiro, K., Pogozheva, I.D., Traynor, J.R., Mosberg, H.I. "Development and in vitro characterization of a novel bifunctional μ-agonist/δ-antagonist opioid tetrapeptide." ACS Chemical Biology, 6(12):1375-1381, 2011.
• Purington, L.C., Pogozheva, I.D., Traynor, J.R., Mosberg, H.I. "Pentapeptidesdisplaying μ-opioid receptor agonist and δ-opioid receptor antagonist/partial agonist properties." Journal of Medicinal Chemistry, 52(23): 7724-7731, 2009.

PRESENTATIONS

• Society for Neuroscience (San Diego, CA) "Interactions between endogenous opioid receptors in SH-SY5Y cells." L.Purington, E. Levitt, H.I. Mosberg, J.R. Traynor, 2010.
• Experimental Biology (New Orleans, LA) "Understanding affinity and efficacy using mixed-action opioid peptides." L.C. Purington, H.I. Mosberg, J.R. Traynor, 2009.

HONORS AND ACHIEVEMENTS

• University of Michigan Graduate Teaching Certificate, Rackham Graduate School and Center for Research on Learning and Teaching, Ann Arbor, MI, 2011.

PROFESSIONAL ORGANIZATION MEMBERSHIP

• Member of the American Society of Phamacology and Experimental Therapeutics (ASPET)

ACPHS COMMITTEES

• MSPS Graduate Admissions Committee