Insong James Lee, Ph.D.
EDUCATION
- Ph.D., Biological Sciences, Department of Biology, University of Pennsylvania, Philadelphia, PA
- B.S., Biological Sciences, Department of Biology, State University of New York at Stony Brook, NY
COURSES TAUGHT AT ACPHS
- PSC-321 and PSC-322: Physiology and Pathophysiology
- PSC-315: Immunology
RESEARCH INTERESTS
- Mechanism of action of cancer preventives and therapeutics.
- Liver toxicity of 3,4-methylenedioxymethamphetamine (MDMA, ecstasy) and alcohol.
- Pharmacogenomics (implementation in the USA healthcare system).
- Detailing the molecular effects of berry extracts (aronia and seabuckthorn) and other natural compounds on cancer cell growth and death.
- Elucidation of the mechanism of drug interaction between MDMA and alcohol.
GRANTS
- Characterization of the anticancer activities of sea buckthorn (Hippophae rhamnoides) berry extracts, CFR&D grant, Notre Dame of Maryland University, Insong James Lee, (PI) 6,000.00 (2015).
- Anticancer effects of claudin protein repression by indole-3-carbinol, NIH EARDA grant # HD046353-04, $10,000. Insong James Lee (PI) (2009).
- Regulation of CYP2B6 in Human Liver, National Institutes of Health: Grant # 2R01DK061652-05A2, $ 1,025,000.00. Wang HB, Lee IJ, Ross D (2007-2011).
- Inhibition of the breast cancer marker MUC1 by the chemo-preventative, Indole-3-carbinol, The Susan G. Komen Breast Cancer Foundation: Grant # BCTR04025132, $ 249,555.00. Lee IJ (PI) (2004).
AWARDS
- Teacher of the year 2014
PROFESSIONAL ORGANIZATIONS
- American Association for the Advancement of Science (AAAS)
- American Association for Cancer Research (AACR)
- American Association of Colleges of Pharmacy (AACP)
- International Society for the Study of Xenobiotics (ISSX)
- The Association of Biochemistry Educator (ABE)
- The Rho Chi Honor Society (RHO)
PUBLICATIONS
- Accessibility and coverage of pharmacogenomics testing by major health insurance companies. Park S, Thigpen J, Lee IJ. (manuscript in preparation).
- Indole-3-carbinol increases the integrity of tight junctions and represses the level of tight junction proteins, claudin-3 and -4 in cancer cells. Kim SK, Hassan HE, Eddington ND, Lee IJ. (manuscript in preparation).
- Increased oxidative-modifications of cytosolic proteins in 3,4- methylenedioxymethamphetamine (MDMA, ecstasy)-exposed rat liver. Upreti VV, Moon K-H, Yu L-R, Lee IJ, Eddington ND, Ye X, Veenstra TD, Song BJ. Proteomics 2011 11(2), 202-211.
- Mechanisms of MDMA (ecstasy)-induced oxidative stress, mitochondrial dysfunction, and organ damage. Song B J, Moon KH, Upreti VV, Eddington ND, Lee IJ. 2010. Current Pharmaceutical Biotechnology 2011, 11(5), 434-443.
- Regulation of gene expression in brain tissues of rats repeatedly treated by the highly abused opioid agonist, oxycodone: microarray profiling and gene mapping analysis. Hassan HE, Myers AL, Lee IJ, Chen H, Coop A, Eddington ND. Drug Metab Dispos. 2010 Jan;38(1):157-67.
- Estradiol and progesterone-mediated regulation of P-gp in P-gp overexpressing cells (NCI-ADR-RES) and placental cells (JAR). Coles LD, Lee IJ, Voulalas PJ, Eddington ND. Mol Pharm. 2009 Nov-Dec;6(6):1816-25.
- Distribution of saquinavir, methadone, and buprenorphine in maternal brain, placenta, and fetus during two different gestational stages of pregnancy in mice. Coles LD, Lee IJ, Hassan HE, Eddington ND. J Pharm Sci. 2009 Aug;98(8):2832-46.
- NMR metabolomic analysis of caco-2 cell differentiation. Lee IJ, Hom K, Bai G, Shapiro M. J Proteome Res. 2009 Aug;8(8):4104-8.
- Drug interaction between ethanol and 3,4-methylenedioxymethamphetamine ("ecstasy"). Upreti VV, Eddington ND, Moon KH, Song BJ, Lee IJ. Toxicol Lett. 2009 Jul 24;188(2):167-72.
- Evaluation of the transport, in vitro metabolism and pharmacokinetics of Salvinorin A, a potent hallucinogen. Teksin ZS, Lee IJ, Nemieboka NN, Othman AA, Upreti VV, Hassan HE, Syed SS, Prisinzano TE, Eddington ND. Eur J Pharm Biopharm. 2009 Jun;72(2):471-7.
ACPHS COMMITTEES
- College Curriculum Committee
- Academic Standing Appeals Committee