Department


Basic & Clinical Sciences

Instructor
Focus: Medicinal Chemistry

Contact Information
(518) 694-7329
daniele.leonard@acphs.edu


Speaker Request
Daniele Leonard, PH.D.

EDUCATION

  • Ph.D. in Biophysical Chemistry, McGill University

COURSES TAUGHT AT ACPHS

  • Chemistry 111 (lab)
  • Chemistry 121 (lab)
  • Chemistry 245 (lecture)

RESEARCH INTERESTS

  • Medicinal Chemistry

PROFESSIONAL AFFILIATIONS:

  • American Chemical Society, member

SELECTED PUBLICATIONS

D.M. Leonard, J.S. Sebolt-Leopold, Ras farnesyltransferase inhibitors.  Drugs of the Future, 24 (10), 1099-1106, 1999.
J.S. Sebolt-Leopold, D.M. Leonard, W.R. Leopold, Histidylbenzylglycinamides: a novel class of farnesyl diphosphate-competitive peptidic farnesyltransferase inhibitors.  In Farnesyltransferase Inhib. Cancer Ther.  Editors: S.M. Sebti, A.D. Hamilton, 103-114, 2001.

J.T. Kohrt, K.J. Filipsi, W.L. Cody, C.F. Bigge, F. La, K. Welch, T. Dahring, J.W. Bryant, D. Leonard, G. Bolton, L. Narasimhan, E. Zhang, J.T. Peterson, S. Haarer, V. Sahasrabudhe, N. Haniczek, S. Desiraju, M. Hena, C. Fiakpui, N. Saraswat, R. Sharma, S. Sun, S.N. Maiti, R. Leadey, J.J. Edmunds, The discovery of glycine and related amino acid-based factor Xa inhibitors.  Bioorg.  Med.  Chem., 14, 4379-4392, 2006.

N.A. Powell, T.J. Hagen, F.L. Ciske, C. Cai, J.E. Duran, D.D. Holworth, D.Leonard, R.M. Kennedy, J.J. Edmunds, Optimization of a Pd-catalyzed intramolecular <alpha>-arylation synthesis of tricyclo-[7.3.1.02,7]-trideca-2,4,6-trien-13-ones, Tetrahedron Lett., 51, 4441-4444, 2010.


PATENTS

K. Ahn, X.-M. Cheng, A.M. Doherty, E.F. Elslager, B. Kornberg, C. Lee, D. Leonard, S. Nikam, L.M. Werbel, Quinazolines as inhibitors of endothelin converting enzyme. United States Patent Number: 5,658,902, issued August 19, 1997.

G.L. Bolton,  A. Campbell, R. Gowan, J.C. Hodges, D. Hupe, D. Leonard, T. Sawyer,  J.Sebolt-Leopold and F.J. Tinney, Substituted Tetra- and Pentapeptide Inhibitors of Protein:Farnesyl Transferase, United States Patent Number 5, 763,577, issued: June 9, 1998.

K. Ahn, X.-M. Cheng, A.M. Doherty, E.F. Elslager, B. Kornberg, C. Lee, D. Leonard, S. Nikam, L.M. Werbel, Quinazolines as inhibitors of endothelin converting enzyme. United States Patent Number: 5,773,444, issued June 30, 1998.

A.M. Doherty, J.S. Kaltenbronn, D. Leonard, J. Quin III and J.D. Scholten, Substituted dinaphthylmethyl, and diheteroarylmethylacetyl histidine inhibitors of protein farnesyl transferase.  United States Patent Number: 6,008,372, issued December 28, 1999.

J.S. Kaltenbronn, D.M. Leonard, J.T. Repine, Benzopyranone and quinolone inhibitors of ras farnesyl transferase. United States Patent Number: 6,143,766, issued November 7, 2000.