Manish Shah - Albany College of Pharmacy and Health Sciences

Education

Assistant Research Professor, University of Connecticut, Storrs, CT
Postdoctoral Fellow and Assistant Project Scientist, University of California, San Diego, CA
Postdoctoral Fellow, Hauptman-Woodward Institute (University at Buffalo), Buffalo, NY

Structure-Function Studies of Cytochrome P450 enzymes – CYP2C8, CYP2C9, and CYP2U1

Invited Reviewer: American Heart Association grants, Transformational Project Awards, Cardiac Biology Committee, 2024 and 2025.
American Heart Association AIREA research grants 2019-2022 and 2022-2024.
Rudolph and Dorothy Blythe Research Award 2023-2025.
Councilor (member of the executive committee) – ASPET Drug Metabolism and Disposition Division, July 2020 – 2023.
Invited to judge student and postdoc posters for the award competition at the The 40th Midwest Enzyme Chemistry Conference, October 2020 – Virtual from University of Texas at Arlington.
Invited Reviewer, NIH MSFA Study Section (Macromolecular Structure and Function A) – 02/2020.
Best Abstract Award – 2012, ASPET – Drug Metabolism Division, Experimental Biology 2012, San Diego, CA
Invited to judge student and postdoc posters for the best abstract award competition at Experimental Biology 2013, Boston, MA.
Councilor to ASPET for postdoctoral fellows – 2012-13 (Drug Metabolism and Disposition division).
Invited grant reviewer of Cytochromes P450 proposal from Austrian Science Fund

“Structural Biology of Human CYP2C9 and CYP2C8: Impact of Genetic Polymorphisms and Ligand Binding – Gordon Research Conference. July 7-12, 2024: Holderness, NH.”
“Crystal Structure of the Human Cytochrome P450 2U1: Insights into the Active Site Architecture of an Orphan P450”. 22nd International Conference on Cytochrome P450 (ICCP450), Washington DC, July 17-21, 2022.
“Fundamentals of Pharmacogenomics: Understanding Genetic Variations and Drug Metabolism”. Albany College of Pharmacy and Health Sciences (ACPHS) Office of Continuing Education and Professional Development. Continuing Pharmacy Education Credit: The Basics of Pharmacogenomics. NY. June 2019.
“Genetic Polymorphisms in Drug Metabolizing Enzymes”. ASPET – Experimental Biology 2019, April 6-9, Orlando, FL.
“Structural Basis of Drug Binding to Polymorphic Cytochrome P450 2C9”. Department of Biochemistry, University at Buffalo, Buffalo, NY February 26, 2019.

Sonia Parikh, Sreeja Edara, Shruti Deodhar, Ajit Singh, Qinghai Zhang, Karen Glass, and Manish B. Shah. Structural and Biophysical Analysis of Cytochrome P450 2C9*14 and *27 Genetic Variants in Complex with Losartan. Journal of Inorganic Biochemistry. 2024. 258: 112622. (Corresponding author).
Arthur G. Roberts, Jeffrey C. Stevens, Grazyna Sklarz, Emily E. Scott, Santosh Kumar, Manish B. Shah, and James R. Halpert. Four decades of CYP2B research: From protein adducts to protein structures and beyond. Drug Metabolism and Disposition. 2023. 51: 111-122.
Manish B. Shah. Inhibition of CYP2C8 by Acyl Glucuronides of Gemfibrozil and Clopidogrel: Pharmacological Significance, Progress and Challenges. Biomolecules. 2022; 12 (9):1218. (Corresponding Author)
Sonia J. Parikh, Sumit Kamat, Margaret Phillips, Samuel P. Boyson, Thomas Yarbrough, Dylan Davie, Qinghai Zhang, Karen C. Glass, and Manish B. Shah*. Insights into the Genetic Variations of Human Cytochrome P450 2C9: Structural Analysis, Characterization and Comparison. International Journal of Molecular Sciences. September 2021. 22 (19), 10206. (Corresponding author)
Sonia Parikh, Chiara Evans, Juliet Obi, Qinghai Zhang, Keiko Maekawa, Karen Glass, and Manish B. Shah*. Structure of Cytochrome P450 2C9*2 in Complex with Losartan: Insights into the Effect of Genetic Polymorphism. Molecular Pharmacology. 2020. 98: 529-39 (Article figure featured on the cover) (*Corresponding author)