Insong Lee

Insong Lee

Education

  • PhD, Biological Sciences, Department of Biology, University of Pennsylvania, Philadelphia, PA
  • BS, Biological Sciences, Department of Biology, State University of New York at Stony Brook, NY

Courses Taught at ACPHS

  • PSC-321 and PSC-322: Physiology and Pathophysiology
  • PSC-315: Immunology
  • PSC-311: Biochemistry

Research Interests

  • Mechanism of action of cancer preventives and therapeutics.
  • Liver toxicity of 3,4-methylenedioxymethamphetamine (MDMA, ecstasy) and alcohol.
  • Pharmacogenomics (implementation in the USA healthcare system).
    • Detailing the molecular effects of berry extracts (aronia and seabuckthorn) and other natural compounds on cancer cell growth and death.
    • Elucidation of the mechanism of drug interaction between MDMA and alcohol.

Learn More About Dr. Lee

  • Characterization of the anticancer activities of sea buckthorn (Hippophae rhamnoides) berry extracts, CFR&D grant, Notre Dame of Maryland University, Insong James Lee, (PI) 6,000.00 (2015).
  • Anticancer effects of claudin protein repression by indole-3-carbinol, NIH EARDA grant # HD046353-04, $10,000. Insong James Lee (PI) (2009).
  • Regulation of CYP2B6 in Human Liver, National Institutes of Health: Grant # 2R01DK061652-05A2, $ 1,025,000.00.  Wang HB, Lee IJ, Ross D (2007-2011).
  • Inhibition of the breast cancer marker MUC1 by the chemo-preventative, Indole-3-carbinol, The Susan G. Komen Breast Cancer Foundation: Grant # BCTR04025132, $ 249,555.00. Lee IJ (PI) (2004).

Teacher of the Year 2014

  • American Association for the Advancement of Science (AAAS)
  • American Association for Cancer Research (AACR)
  • American Association of Colleges of Pharmacy (AACP)
  • International Society for the Study of Xenobiotics (ISSX)
  • The Association of Biochemistry Educators (ABE)
  • The Rho Chi Honor Society (RHO)

  • Accessibility and coverage of pharmacogenomics testing by major health insurance companies.  Park S, Thigpen J, Lee IJ. (manuscript in preparation).
  • Indole-3-carbinol increases the integrity of tight junctions and represses the level of tight junction proteins, claudin-3 and -4 in cancer cells.  Kim SK, Hassan HE, Eddington ND, Lee IJ. (manuscript in preparation).
  • Increased oxidative-modifications of cytosolic proteins in 3,4- methylenedioxymethamphetamine (MDMA, ecstasy)-exposed rat liver.  Upreti VV, Moon K-H, Yu L-R, Lee IJ, Eddington ND, Ye X, Veenstra TD, Song BJ.  Proteomics 2011 11(2), 202-211.
  • Mechanisms of MDMA (ecstasy)-induced oxidative stress, mitochondrial dysfunction, and organ damage.  Song B J, Moon KH, Upreti VV, Eddington ND, Lee IJ.  2010. Current Pharmaceutical Biotechnology 2011, 11(5), 434-443.
  • Regulation of gene expression in brain tissues of rats repeatedly treated by the highly abused opioid agonist, oxycodone: microarray profiling and gene mapping analysis.  Hassan HE, Myers AL, Lee IJ, Chen H, Coop A, Eddington ND.  Drug Metab Dispos. 2010 Jan;38(1):157-67.

  • College Curriculum Committee
  • Academic Standing Appeals Committee