Marcel Musteata

Marcel Musteata

Education

  • Postdoctoral, University of Toronto
  • PhD, University of Waterloo

Courses Taught at ACPHS

  • Pharmacokinetics
  • Pharmaceutical Analysis
  • Pharmaceutical Sciences Research Experience

Research Interests

  • Pharmacokinetic-pharmacodynamic modeling of anticancer drugs
  • Minimally invasive sampling and analysis of drugs and endogenous compounds
  • Development of miniaturized devices that integrate chemical analysis, decision, and drug delivery

Learn More About Dr. Musteata

Musteata F.M.* “Dosing Adjustments in Cases of Altered Plasma Protein Binding are Most Needed for Drugs with a Volume of Distribution Below 1.3 L/kg” Clinical Pharmacokinetics, vol. 63, p. 1111-1119, https://doi.org/10.1007/s40262-024-01403-1, 2024

Klock E., Kane M., and Musteata F.M.: “Using Comprehensive Ultrafiltration for Simultaneous Measurement of the Free Fraction, Total Concentration, and Protein Binding for Testosterone, Triiodothyronine, and Thyroxine in Clinical Samples,” Bioanalysis, https://doi.org/10.4155/bio-2023-0126, 2023

Adegbite B.O., Abramson M.H., Gutgarts V., Musteata F.M., Chauhan K., Muwonge A.N., Meliambro K.A., Salvatore S.P., El Ghaity-Beckley S., Kremyanskaya M., Marcellino B., Mascarenhas J.O., Campbell K.N., Chan L., Coca S.G., Berman E.M., Jaimes E.A., Azeloglu E.U.: “Patient-specific pharmacokinetics and dasatinib nephrotoxicity,” Clinical Journal of the American Society of Nephrology, 18, p. 1175-1185, https://doi.org/10.2215/CJN.0000000000000219, 2023

Cibotaru D., Celestin M.N., Kane M., and Musteata F.M.: “Comparison of liquid–liquid extraction, microextraction and ultrafiltration for measuring free concentrations of testosterone and phenytoin,” Bioanalysis, 14(4), p. 195-204, https://doi.org/10.4155/bio-2021-0249, 2022

Celestin M.N. and Musteata F.M.: “Impact of Changes in Free Concentrations and Drug-Protein Binding on Drug Dosing Regimens in Special Populations and Disease States,” Journal of Pharmaceutical Sciences, 110(10), p. 3331-3344, doi: 10.1016/j.xphs.2021.05.018, 2021

Mall I, Zheng H, Musteata FM. Transdermal Sampling of Vitamin D3 and 25-Hydroxyvitamin D3. AAPS-NERDG, Farmington CT, April 2018.

Role: Co-Principal Investigator: Marcel Musteata (Co-PI: Michael Kane, ACPHS)
Project Title: Simultaneous Determination of Free, Total, and Normalized Concentrations of Bioactive Compounds
Grantor: National Institutes of Health, National Institute of General Medical Sciences
Grant Number: 1R15GM126510-01
Amount: $480,000
Term: 2018-2021

Associate Editor for Bioanalysis