Provost and Vice President of Academic Affairs
Focus: Molecular Pharmacology
Tarun B. Patel, Ph.D., began as Provost and Vice President of Academic Affairs of Albany College of Pharmacy and Health Sciences on July 1, 2015. In this role, he oversees all areas of the College related to academic programming, research and scholarship, student affairs, and faculty development.
Prior to joining ACPHS, Dr. Patel was a Professor in the Department of Molecular Pharmacology and Therapeutics at Loyola University Chicago’s Stritch School of Medicine. He was recruited by the School of Medicine to be Chair of the Department of Molecular Pharmacology and Therapeutics and served in that role for nearly ten years.
He also served as Professor in the Department of Pharmacology at the College of Medicine on the University of Tennessee Health Science Center campus in Memphis, TN.
- Postdoctoral Fellow, Department of Biochemistry, The University of Texas Health Center at San Antonio. Supervisor: Dr. Merle S. Olson.
- Ph.D. in Biochemistry (University of London) The Medical College of St. Bartholomew's Hospital. Supervisor: Dr. J.B. Clark.
- B.Sc. with honors (University of London) Queen Elizabeth College Cambden Hill Road, London
- Elucidation mechanisms involved in hepatocellular carcinoma with emphasis on the role of Sprouty proteins in this disease.
SUMMARY OF PROFESSIONAL EXPERIENCE
- Research Health Scientist, Edward Hines, Jr. VA Hospital, Hines, IL (2014-2015)
- Professor, Department of Molecular Pharmacology and Therapeutics, Loyola University Chicago, Stritch School of Medicine (2003-2015)
- Professor, Department of Pharmacology, The University of Tennessee, Memphis, The Health Science Center (1992- 2003)
- Associate Professor, Department of Pharmacology, The University of Tennessee, Memphis, The Health Science Center (1987-1992)
- Assistant Professor, Department of Pharmacology, The University of Tennessee, Memphis, The Health Science Center (1984-1987)
- Research Assistant Professor, Department of Biochemistry, The University of Texas Health Science Center at San Antonio (1983-1984)
- Research Instructor, Department of Biochemistry, The University of Texas Health Science Center at San Antonio (1982-1983)
- Postdoctoral Fellow, Dept. of Biochemistry, Univ. of Texas Health Science Center at San Antonio (1979-1981)
- Chair, Department of Molecular Pharmacology and Therapeutics, Loyola University Chicago, Stritch School of Medicine (2003-2010, 2012)
- Director, Signal Transduction Research Institute, Loyola University Chicago, Stritch School of Medicine (2010-2015)
- Leader, Oncology Institute's Program in Signaling & Experimental Therapeutics (2012-2015)
- The Biochemical Society (London)
- American Society for Biochemistry and Molecular Biology
- American Society for Pharmacology and Experimental Therapeutics
- Alliance for Cell Signaling
- American Soc. for Microbiology
- American Society of Cell Biology
- American Heart Association
- American Medical Schools Pharmacology Chairs Association
Throughout the course of his academic career, Dr. Patel has received more than 30 externally funded grants, including 16 grants from the National Institutes of Health.
Award: Role of Sprouty2 in Hepatocellular Carcinoma. P.I: Tarun B. Patel. Percent Effort: 62.5% (transferrable and effort negotiable with memorandum of understanding between the VA and partnering Academic Institution). Percentile: 1.1 - Direct costs: $1,000,053. Funding period: 01/01/2014 - 12/3112017.
NIH: Mechanisms of Impaired Erythropoiesis in Post Burn Anemia of Critical Illness. (lR01DK097760-01) P.I. K. Muthumalaiappan, Collaborator: Tarun B. Patel. Percent Effort: 2%. Funding period: 06/1512013 - 04/30/2018.
Planned and Pending Funding
VA: Acquisition of Vevo 2100 Imaging System (Shared Equipment Grant) 1IS IBX003] 3401. P.I.: Tarun B. Patel (Pending Review)
NIH: Cross-Talk between Sprouty2 & Hypoxia Inducible Factors. P.I.: Tarun B. Patel. Percent Effort 30% (Planned for Submission)
NIH: Interactions Between p90 Ribosomal S6 Kinase and Protein Kinase A. P.I: Tarun B. Patel. Percent Effort: 10%.08115/07- 07/31/13 (Renewal planned)
Dow,A. L.; Lin,T. V.; Chartoff,E. H.; Potter,D.; McPhie,D. L.; Van't Veer,A. V.; Knoll,A. T.; Lee,K. N.; Neve,R. L.; Patel,T. B.; Ongur,D.; Cohen,B. M.; Carlezon,W. A.,JrSprouty2 in the dorsal hippocampus regulates neurogenesis and stress responsiveness in rats PLoS ONE 2015 ;10(3):e0120693.
Ha,G. H.; Kim,J. L.; Petersson,A.; Oh,S.; Denning,M. F.; Patel,T.; Breuer,E. K.TACC3 deregulates the DNA damage response and confers sensitivity to radiation and PARP inhibition Oncogene 2014:10.1038/onc.2014.105.
Patel,T.; Song,A. J.; Lomasney,L. M.; Demos,T. C.; Dickey,S.Acute fibular sesamoid fracture: one part of the spectrum of sesamoid pathologies Orthopedics 2014 ;37(10):650-711.
Ellimoottil,C.; Greco,K. A.; Hart,S.; Patel,T.; Sheikh,M. M.; Turk,T. M.; Flanigan,R. C.New Modalities for the Evaluation and Surveillance of Complex Renal Cysts The Journal of urology 2014.
Gao,X.; Lin,B.; Sadayappan,S.; Patel,T. B.Interactions between the Regulatory Subunit of Type I Protein Kinase A (PKARIalpha) and p90 Ribosomal S6 Kinase1 (RSK1) Regulate Cardiomyocyte Apoptosis Molecular pharmacology 2013.
Gao,X.; Chaturvedi,D.; Patel,T. B.Localization and retention of p90 ribosomal S6 kinase 1 in the nucleus: implications for its function Molecular biology of the cell 2012 ;23(3):503-515.
Anderson,K.; Nordquist,K. A.; Gao,X.; Hicks,K. C.; Zhai,B.; Gygi,S. P.; Patel,T. B.Regulation of cellular levels of Sprouty2 protein by prolyl hydroxylase domain and von Hippel-Lindau proteins The Journal of biological chemistry 2011 ;286(49):42027-42036.
Wietecha,M. S.; Chen,L.; Ranzer,M. J.; Anderson,K.; Ying,C.; Patel,T. B.; DiPietro,L. A.Sprouty2 downregulates angiogenesis during mouse skin wound healing American journal of physiology.Heart and circulatory physiology 2011 ;300(2):H459-67.
Edwin,F.; Anderson,K.; Patel,T. B.HECT domain-containing E3 ubiquitin ligase Nedd4 interacts with and ubiquitinates Sprouty2. Journal of Biological Chemistry 2010 ;285(1):255-264.
Gao,X.; Chaturvedi,D.; Patel,T. B.p90 ribosomal S6 kinase 1 (RSK1) and the catalytic subunit of protein kinase A (PKA) compete for binding the pseudosubstrate region of PKAR1alpha: role in the regulation of PKA and RSK1 activities. Journal of Biological Chemistry 2010 ;285(10):6970-6979.
Gao,X.; Patel,T. B.Regulation of protein kinase A activity by p90 ribosomal S6 kinase 1. Journal of Biological Chemistry 2009 ;284(48):33070-33078.
Edwin,F.; Anderson,K.; Ying,C.; Patel,T. B.Intermolecular interactions of Sprouty proteins and their implications in development and disease Molecular pharmacology 2009 ;76(4):679-691.
Chaturvedi,D.; Cohen,M. S.; Taunton,J.; Patel,T. B.The PKARIalpha subunit of protein kinase A modulates the activation of p90RSK1 and its function. Journal of Biological Chemistry 2009 ;284(35):23670-23681.
Chaturvedi,D.; Gao,X.; Cohen,M. S.; Taunton,J.; Patel,T. B.Rapamycin induces transactivation of the EGFR and increases cell survival. Oncogene 2009 ;28(9):1187-1196.
Patel,T.; Hirter,A.; Kaufman,J.; Keithi-Reddy,S. R.; Reda,D.; Singh,A.Route of epoetin administration influences hemoglobin variability in hemodialysis patients. American Journal of Nephrology 2009 ;29(6):532-537.
Johnson,S.; Schriever,C.; Patel,U.; Patel,T.; Hecht,D. W.; Gerding,D. N.Rifaximin Redux: treatment of recurrent Clostridium difficile infections with rifaximin immediately post-vancomycin treatment. Anaerobe 2009 ;15(6):290-291.
Edwin,F.; Patel,T. B.A novel role of Sprouty 2 in regulating cellular apoptosis. Journal of Biological Chemistry 2008 ;283(6):3181-3190.
Dai,Y.; Dudek,N. L.; Patel,T. B.; Muma,N. A.Transglutaminase-catalyzed transamidation: a novel mechanism for Rac1 activation by 5-hydroxytryptamine2A receptor stimulation. Journal of Pharmacology & Experimental Therapeutics 2008 ;326(1):153-162.
Gao,X.; Sadana,R.; Dessauer,C. W.; Patel,T. B.Conditional stimulation of type V and VI adenylyl cyclases by G protein betagamma subunits. Journal of Biological Chemistry 2007 ;282(1):294-302.
Ongur,D.; Pohlman,J.; Dow,A. L.; Eisch,A. J.; Edwin,F.; Heckers,S.; Cohen,B. M.; Patel,T. B.; Carlezon,W. A.,JrElectroconvulsive seizures stimulate glial proliferation and reduce expression of Sprouty2 within the prefrontal cortex of rats. Biological psychiatry 2007 ;62(5):505-512.
Wiepz,G. J.; Edwin,F.; Patel,T.; Bertics,P. J.Methods for determining the proliferation of cells in response to EGFR ligands. Methods in Molecular Biology 2006 ;327:179-187.
Di Cesare Mannelli,L.; Pacini,A.; Toscano,A.; Ghelardini,C.; Manetti,D.; Gualtieri,F.; Patel,T. B.; Bartolini,A.A recombinant transductor-effector system: in vitro study of G inhibitory protein (G-alpha-i1) direct activators. Archives of Biochemistry & Biophysics 2006 ;453(2):151-160.
Chaturvedi,D.; Edwin,F.; Sun,H.; Patel,T. B.Analysis of EGF receptor interactions with the alpha subunit of the stimulatory GTP binding protein of adenylyl cyclase, Gs. Methods in Molecular Biology 2006 ;327:49-59.
Chaturvedi,D.; Poppleton,H. M.; Stringfield,T.; Barbier,A.; Patel,T. B.Subcellular localization and biological actions of activated RSK1 are determined by its interactions with subunits of cyclic AMP-dependent protein kinase. Molecular & Cellular Biology 2006 ;26(12):4586-4600.
Edwin,F.; Singh,R.; Endersby,R.; Baker,S. J.; Patel,T. B.The tumor suppressor PTEN is necessary for human Sprouty 2-mediated inhibition of cell proliferation. Journal of Biological Chemistry 2006 ;281(8):4816-4822.
Edwin,F.; Wiepz,G. J.; Singh,R.; Peet,C. R.; Chaturvedi,D.; Bertics,P. J.; Patel,T. B.A historical perspective of the EGF receptor and related systems Methods in Molecular Biology 2006 ;327:1-24.
Gordon,K. B.; Bonish,B. K.; Patel,T.; Leonardi,C. L.; Nickoloff,B. J.The tumour necrosis factor-alpha inhibitor adalimumab rapidly reverses the decrease in epidermal Langerhans cell density in psoriatic plaques. British Journal of Dermatology 2005 ;153(5):945-953.
Zhang,C.; Chaturvedi,D.; Jaggar,L.; Magnuson,D.; Lee,J. M.; Patel,T. B.Regulation of vascular smooth muscle cell proliferation and migration by human sprouty 2. Arteriosclerosis, Thrombosis & Vascular Biology 2005 ;25(3):533-538.
Gao,X.; Du,Z.; Patel,T. B.Copper and zinc inhibit Galphas function: a nucleotide-free state of Galphas induced by Cu2+ and Zn2+. Journal of Biological Chemistry 2005 ;280(4):2579-2586.
Gao,X.; Patel,T. B.Histidine residues 912 and 913 in protein associated with Myc are necessary for the inhibition of adenylyl cyclase activity. Molecular pharmacology 2005 ;67(1):42-49.
Deng,W.; Poppleton,H.; Yasuda,S.; Makarova,N.; Shinozuka,Y.; Wang,D. A.; Johnson,L. R.; Patel,T. B.; Tigyi,G.Optimal lysophosphatidic acid-induced DNA synthesis and cell migration but not survival require intact autophosphorylation sites of the epidermal growth factor receptor The Journal of biological chemistry 2004 ;279(46):47871-47880.
Patel,T.; Gordon,K. B.Adalimumab: efficacy and safety in psoriasis and rheumatoid arthritis Dermatologic Therapy 2004 ;17(5):427-431.
Patel,T. B.Single transmembrane spanning heterotrimeric g protein-coupled receptors and their signaling cascades Pharmacological reviews 2004 ;56(3):371-385.
Poppleton,H. M.; Edwin,F.; Jaggar,L.; Ray,R.; Johnson,L. R.; Patel,T. B.Sprouty regulates cell migration by inhibiting the activation of Rac1 GTPase. Biochemical & Biophysical Research Communications 2004 ;323(1):98-103.
Yigzaw,Y.; Poppleton,H. M.; Sreejayan,N.; Hassid,A.; Patel,T. B.Protein-tyrosine phosphatase-1B (PTP1B) mediates the anti-migratory actions of Sprouty The Journal of biological chemistry 2003 ;278(1):284-288.
Du,Z.; Patel,T. B.Albumin: a Galpha(s)-specific guanine nucleotide dissociation inhibitor and GTPase activating protein ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 2003 ;415(2):221-228.
Patel,T. B.; Wittpoth,C.; Barbier,A. J.; Yigzaw,Y.; Scholich,K.Functional analyses of type V adenylyl cyclase Methods in enzymology 2002 ;345:160-187.
Yang,H.; Scholich,K.; Poser,S.; Storm,D. R.; Patel,T. B.; Goldowitz,D.Developmental expression of PAM (protein associated with MYC) in the rodent brain Brain Research.Developmental Brain Research 2002 ;136(1):35-42.
- Chair: Partial Site Visit of NICHD intramural funded programs (Spring 2014)
- Chair: Molecular Signaling (4) Study Section of AHA (20l2-Present)
- Member: AHA LOI review Committee (Fall 2013)
- Co-Chair: Site visit team of the Unit on Human Copper Metabolism intramural
- program ofNICHD (Nov. 16, 2012)
- Co-Chair: Site visit team of the PDGENintramural program ofNICHD (March 21/23, 2012)
- Co-Chair: Site visit team of the PCRM and LCDG intramural programs ofNICHD (Oct 20/21, 2011)
- Member: Board of Scientific Counselors, NICHD (May 1, 2010 - Present)
- Member: AHA Molecular Signaling 2 study section (March 2010 - Present)
- Member: Review Committee for LOI to apply for Multi-PI/multi-institutional awards from the American Heart Association (Nov/Dec 2013)
- Member: NIH: ARRA R15 application review panel (December 2009)
- Member: NIH Special Emphasis Panel (Oct 2008, Feb 2009, July 2009)
- Member: NIH SEP: Cell Biology Group (July/Aug 2007)
- Member: NIH SEP: Protein-Protein Interactions (Nov 2006)
- Member: NIH Special Emphasis Panel to review Institutional Training Grants (Oct 2005)
- Member: Schweppe Foundation Research Advisory Board (2004- 2009)
- Member: NIH Physiological Chemistry Study Section (2001-2005)
- Teacher of the Year Award (2004)
- Sigma Xi Award for Excellence in Research (1996)
- Member: Cardiovascular Study Section of the California Tobacco Related Disease Research Program (1993 & 1994)
- Member: Research Committee (Policy & Funding Decisions) of the American Heart Association, SE Affiliate (1995-2003)
- Member: Research Review Committee of the American Healt Assoc-TN Affiliate (1990-1995)
- Member: NIH Medical Biochemistry Study Section (1989-1993)
- Recipient of NIH Research Career Development Award, (1987-1992)
- Recipient of Students Research Council Fellowship (1975-1978)