Department


Pharmaceutical Sciences

Associate Professor
Focus: Epigenetics

Contact Information
(802) 735-2636
karen.glass@acphs.edu


Speaker Request
Karen C. Glass, PH.D.

Visit the Glass Lab website

EDUCATION
  • Postdoctoral, Pharmacology, University of Colorado Denver, Denver, CO (Advisor: Dr. Tatiana G. Kutateladze)
  • Postdoctoral, Molecular, Cell and Developmental Biology, University of California Santa Cruz, Santa Cruz, CA (Advisor: Dr. Harry F. Noller)
  • Ph.D., Microbiology & Molecular Genetics, University of Vermont, Burlington, VT (Advisor: Dr. Christopher S. Francklyn)
  • B.S.,  Microbiology, University of Massachusetts, Amherst, MA (Advisor: Dr. Steven J. Sandler)  
POSITIONS
  • 05/16 - present - Associate Professor, Department of Pharmaceutical Sciences, Albany College of Pharmacy and Health Sciences (ACPHS), Vermont Campus
  • 08/11 - present - Adjunct Assistant Professor, Department of Biochemistry, College of Medicine, University of Vermont (UVM)
  • 08/10 - 05/16 - Assistant Professor, Department of Pharmaceutical Sciences, Albany College of Pharmacy and Health Sciences (ACPHS), Vermont Campus
  • 08/09 - 12/09 - Affiliate Professor, Department of Biology, Metropolitan State College, Denver, CO           
 COURSES TAUGHT AT ACPHS
  • Molecular Biology 
  • Pharmacogenomics 
  • Macromolecular Structure 
  • Infectious Disease
  • Cardiovascular PTPM
  • Principles of Pharmacology and Medicinal Chemistry 
RESEARCH GRANTS
  • 1R01GM129338-01 (Glass, KC), 09/19/2018 – 08/31/2022 National Institute of General Medical Sciences of the National Institutes of Health "Deciphering the molecular mechanisms of histone code recognition by ATAD2/B".
  • 2R15GM104865-02 (Glass, KC), 02/01/2016-01/31/2019 National Institute of General Medical Sciences of the National Institutes of Health  “Mechanisms of chromatin binding and selection by family IV bromodomains”.
  • R15GM104865 (Glass, KC), 1/13 - 12/15 National Institute of General Medical Sciences of the National Institutes of Health "A unique double PHD finger and bromodomain in epigenetic signaling".
  • 10BGIA3420014 (Glass, KC),  7/10-6/12 American Heart Association PMA Beginning Grant-in-Aid “The Structural Role of PHD Finger Domains in Chromatin Remodeling”.
  • F32 GM083462 (Champagne, KS), 7/08-8/10 National Research Service Award, postdoctoral fellowship “The Structural Role of PHD Finger Domains in Chromatin Remodeling”.
  • 08-049-01-GMC (Champagne, KS) (Terminated on 6/30/2008), 01/08-12/10 American Cancer Society, postdoctoral fellowship “The Structural Role of PHD Finger Domains in Chromatin Remodeling”.
  • Vermont DOE EPSCoR graduate research fellowship. 2001-2003.
  • Howard Hughes grant for undergraduate research. 1999. 
  • Honors Research Grant for undergraduate thesis research. 1998.
HONORS AND ACHIEVEMENTS
  • 2014 - ACPHS Researcher of the year award
  • 2012 - ASBMB annual meeting thematic best poster in the Gene Regulation category
  • 2011 - Poster presentation award winner in the Faculty/Staff category. Vermont Cancer Center's Clinical and Translational Research Symposium: DNA Repair & Cancer.
  • 2010 - Poster presentation award winner in the Faculty/Staff category. Vermont Cancer Center's Clinical and Translational Research Symposium: Inflammation & Cancer.
  • 2010 - Poster presentation award. University of Colorado Denver Postdoctoral Research Day.
  • 2008 - Post-Doctoral Award for Outstanding Achievement, Department of Pharmacology, University of  Denver (UC Denver), School of Medicine.
  • 2008 - Keystone Symposia Scholarship, ‘Molecular Basis for Chromatin Modifications and Epigenetic Phenomena’, Snowmass, CO.
  • 2008 - American Heart Association, postdoctoral fellowship (declined).
  • 2004 - Travel award from the University of Vermont (UVM) graduate college for a tRNA Synthetase conference, Seoul, Korea.
  • 2001 - American Crystallography Association student travel grant, ACA meeting, Los Angeles, CA.
  • 1999 - Graduated with honors, Magna Cum Laude.
  • 1997 - Golden Key National Honors Society, member.
  • 1996 - Alpha Lambda Delta, a national academic honors society for freshmen in the top 10% of their class, member.
    PROFESSIONAL AFFILIATIONS
    • 2014 - Present: Member, UVM Cellular, Molecular, and Biomedical Sciences Program
    • 2013 - Present: Member, UVM Graduate Faculty
    • 2011 - Present: Member, University of Vermont Cancer Center
    • 2011 - Present: Member, American Society for Biochemistry and Molecular Biology
    • 2010 - Present: Member, American Crystallographic Association
    ACPHS COMMITTEES
    • 2016 - Present: Member, Academic Standings and Appeals Committee 
    • 2015 - Present: Member, Faculty Senate
    • 2012 - Present: Member, Graduate Faculty Curriculum Committee (Chair from 2012-2014)
    • 2015 - 2018: Member, Research Committee
    • 2014 - 2015: Member, Pharmacy Admissions & Academic Standards Committee (PAASC)
    • 2010 - 2015: Member, Academic Standings Committee 

    PUBLICATIONS

    Gay JC, Eckenroth BE, Evans CE, Langini C, Carlson C, Lloyd JT, Caflisch A, Glass KC. (2018) Disulfide bridge formation influences ligand recognition by the ATAD2 bromodomain. Proteins: Structure, Function, and Bioinformatics, Dec. 6, doi: 10.1002/prot.25636. [Epub ahead of print]. PMID: 30520161.

    Doyle JW, Glass KC, Racz M, Teng J. (2018) Student-Directed Interactive Animation for Learning Cytochrome P450-Mediated Drug Metabolism. Currents in Pharmacy Teaching and Learning, Dec 10(12):1565-1573. PMID: 30527821.

    Lloyd JT, Glass KC. (2018) Biological function and histone recognition of family IV bromodomain-containing proteins. Journal of Cellular Physiology, Mar;233(3):1877-1886. doi: 10.1002/jcp.26010. Epub 2017 Jun 13. PMID: 28500727.

    CONFERENCES AND PRESENTATIONS

    Glass KC. A link between ATAD2 bromodomain disulfide bridge formation and cancer progression? ACPHS Annual Research Forum, Albany NY, January 27, 2018 (Invited talk).

    Lloyd JT, Gay JC, Eckenroth BE, Tonelli M, Cornilescu G, Nguyen P, Carlson S, Markley JL, Glass KC. Structural insights into the recognition of mono- and di-acetyllysine by the ATAD2B bromodomain. ACPHS Annual Research Forum, Albany NY, Jan 27, 2018 (Poster presenter: KC Glass).

    Lloyd JT, Gay JC, Eckenroth BE, Tonelli M, Cornilescu G, Nguyen P, Carlson S, Markley JL and Glass KC. Structural insights into the recognition of mono- and di-acetyllysine by the ATAD2B bromodomain. Keystone Symposia on Cancer Epigenetics: New Mechanisms, New Therapies, Breckenridge CO, February 12, 2018 (Poster presenter: KC Glass).

    Lloyd JT, Gay JC, Eckenroth BE, Tonelli M, Cornilescu G, Nguyen P, Carlson S, Markley JL and Glass KC. Structural insights into the recognition of mono- and di-acetyllysine by the ATAD2B bromodomain. UVM Clinical and Translational Research Symposium on Cancer Control in a Rural Environment, Burlington VT, April 20, 2018 (Poster presenter: KC Glass).

    Evans CM, Gay JC, Eckenroth BE, Carlson S, Lloyd JT, Glass KC. Disulfide bridge formation contributes to histone ligand recognition by the ATAD2 bromodomain. ACPHS Annual Research Forum, Albany NY, Jan 27, 2018 (Poster presenter: Chiara Evans).

    Evans CM, Gay JC, Eckenroth BE, Carlson S, Lloyd JT, Glass KC. Disulfide bridge formation contributes to histone ligand recognition by the ATAD2 bromodomain. Keystone Symposia on Cancer Epigenetics: New Mechanisms, New Therapies, Breckenridge CO, February 12, 2018 (Poster presenter: Chiara Evans). 

    Evans CM, Gay JC, Eckenroth BE, Carlson S, Lloyd JT, Glass KC. Disulfide bridge formation contributes to histone ligand recognition by the ATAD2 bromodomain. ACPHS Annual Student Research Symposium, Albany NY, April 3, 2018 (Poster presenter: Chiara Evans).

    Evans CM, Gay JC, Carlson S, Glass KC. Recognition of acetylated histone ligands by the ATAD2 bromodomain. AAPS-NERDG 2018 Annual Meeting, Farmington CT, April 12, 2018 (Poster presenter: Chiara Evans) **Recipient of the 2018 AAPS-ACPHS Student Researcher Award.

    Signorelli S, Gerrard D, Glass KC, Frietze S. Genome-Wide Analysis of Bromodomain Histone Di-Acetyllysine Ligands. UVM Undergraduate Research Conference, Burlington VT, April 19, 2018 (Poster presenter: Sylvia Signorelli).

    Signorelli S, Gerrard D, Glass KC, Frietze S. Genome-Wide Analysis of Bromodomain Histone Di-Acetyllysine Ligands. UVM Clinical and Translational Research Symposium on Cancer Control in a Rural Environment, Burlington VT, April 20, 2018 (Poster presenter: Sylvia Signorelli).

    Signorelli S, Gerrard D, Glass KC, Frietze S. Genome-Wide Analysis of Bromodomain Histone Di-Acetyllysine Ligands. ASBMB Annual Meeting, San Diego CA, April 21-25, 2018 (Poster presenter: Sylvia Signorelli).

    Evans CM, Gay JC, Eckenroth BE, Carlson S, Lloyd JT, Glass KC. Disulfide bridge formation contributes to histone ligand recognition by the ATAD2 bromodomain. ASBMB Annual Meeting, San Diego CA, April 21-25, 2018 (Poster presenter: Chiara Evans) **Recipient of an ASBMB 2018 Graduate/Postdoctoral Travel Award, $1000. 

    Allen B, Olmstead F, Evans CM, Glass KC. Characterization of the Histone Ligands of the Plasmodium falciparum BDP1 Bromodomain. ACPHS Student Summer Research Award Presentation, Albany NY, October 27, 2018 (Poster presenter: Brittany Allen) **Recipient of an ACPHS Summer Student Research Award.

    EXTRAMURAL GRANTS 

     

    Role: Co-Principal Investigator (Co-PI: Seth Frietze, University of Vermont)

    Project Title: Deciphering the molecular mechanisms of histone code recognition by ATAD2/B
    Grantor: National Institutes of Health, National Institute of General Medical Sciences
    Grant Number: 1R01GM129338-01
    Amount: $1,987,375
    Term: 9/19/2018 – 8/31/2022

    HONORS, AWARDS, AND APPOINTMENTS

    Peer reviewer for Cell Death & Disease, Journal of Medicinal Chemistry, PLOS ONE, and the Journal of Cellular Physiology.

    Ad hoc reviewer for NIH Center for Scientific Review Molecular Genetics A study (MGA) section meeting. 9/24 to 9/25/2018.