Academics


Department of Pharmaceutical Sciences

Comprised of faculty that span pharmaceutical and pharmacological research, the Department of Pharmaceutical Sciences on the Albany Campus is in the process of expanding and strengthening its research portfolio.

Existing areas of expertise include drug delivery, drug discovery, bioanalytical technologies, cell signaling, pharmacokinetics, pharmacodynamics, and neuroscience (view the below list of recent scholarly activity for additional insights into the research being conducted by members of the Department).

The Department supports both the bachelor’s and master’s degree programs in Pharmaceutical Sciences in addition to teaching courses in the Doctor of Pharmacy program.

Departmental faculty are centralized in the Biosciences Research Building (BRB) which houses a mass spectrometer and a cell culture facility and provides a dynamic collaborative environment for research. Faculty also have access to the College’s Pharmaceutical Research Institute (PRI), which occupies premier lab space at the University at Albany’s Health Sciences campus in nearby Rensselaer, NY.

Departmental Faculty

 

2016 scholarly activity report

The activities listed below are by members of the Department of Pharmaceutical Sciences on the Albany Campus and span the period from January 1, 2016 - December 31, 2016.

publications

PEER REVIEWED ARTICLES

Yana Cen
Wood M, Cen Y. Facile Synthesis of NaMN, NaAD and Derivatives. Annals of Pharmacology & Pharmaceutics, 2016, 1, 1007.

Subramaniam R, Jagadeesan R, Mathew I, Cen Y, Balaz S. Scalable Synthesis and Purification of Acetylated Phosphatidyl Choline Headgroup. Organic Process Research & Development, 2017, 21, 177-181. .

Karen Glass
Kim S, Natesan S, Cornilescu G, Carlson S, Tonelli M, McClurg UL, Binda O, Robson CN, Markley JL, Balaz S, Glass KC. Mechanism of Histone H3K4me3 Recognition by the Plant Homeodomain of Inhibitor of Growth 3. Journal of Biological Chemistry 2016, 291, 18326-18341.

Hassan HE, Keita JA, Narayan L, Brady SM, Frederick R, Carlson S, Glass KC, Natesan S, Buttolph T, Fandy TE. The combination of dimethoxycurcumin with DNA methylation inhibitor enhances gene re-expression of promoter-methylated genes and antagonizes their cytotoxic effect. Epigenetics 2016, 11, 740-749.

Marcel Musteata
Singh A, Bartiss R, Rahman T, Arabshahi A, Prasain J, Barnes S, Musteata FM, Sellati TJ. Lipoxin A4, a 5-lipoxygenase pathway metabolite, modulates immune response during acute respiratory tularemia. Journal of Leukocyte Biology, September 14, 2016 (published online before print).

Musteata FM, Sandoval M, Ruiz JM, Harrison K, McKenna D, Millington W. Rapid, Minimally Invasive Analysis of Amazonian Plants Using Solid Phase Microextraction, Phytochemical Fingerprinting, and LC-MS. Analytica Chimica Acta, 933, p. 124-133, 2016.

Musteata FM. Making Sense of Vitamin D Concentrations. Future Science OA, 2(1), doi 10.4155/fso.15.90, 2016.

HaiAn Zheng
Alsharif NZ, Abrons JP, Williams D, Zheng HA, Ombengi DN, Dakkuri A, Al­Dahir S, Tofade T, Gim S, O’Connell MB. Global/International Advanced Pharmacy Practice Experiences: Host Country, Site and Institution Considerations. American Journal of Pharmacy Education, 25;80(3):38. 2016

BOOK CHAPTERS

James M. Gallo
Birtwistle MR, Hansen J, Gallo JM, Muppirisetty S, Man-Ung P, Iyengar R, Schlessinger A. “Systems Pharmacology: An Overview” in Systems Pharmacology and Pharmacodynamics. D.E. Mager and H.C. Kimko, Eds., American Association of Pharmaceutical Scientists, Springer (ISBN: 978-3-319-44532-8), 2016.

HaiAn Zheng
Zheng HA, Crison J. “Drug Delivery and Product Design” in Martin’s Physical Pharmacy and Pharmaceutical Sciences, 7th edition. Edited by Patrick Sinko, Lippincott Williams & Wilkins, December 2016, ISBN, 9781496353443.

Wu L, Smith H, Zheng HA, Yu L. “Drug Product Approval in the United States and International Harmonization” in Developing Oral Solid Dosage Forms. Academic Press, 2nd edition, November 2016, ISBN: 9780128024478.

CONFERENCES AND PRESENTATIONS

Yana Cen
Graham E, Wood M, Rymarchyk S, Zhang K, Lin H, Cen Y. Chemical Biology Approach for Sirtuin Profiling. Sixth Annual ACPHS Research Forum, Albany, NY, January 23, 2016 (oral presentation).

Graham E, Rymarchyk S, Cen Y. Design and Synthesis of Activity-based Chemical Probes for Specific Sirtuin Isoforms. Sixth Annual ACPHS Research Forum, Albany, NY, January 23, 2016 (poster presentation).

Cen Y. Novel Probes for Sirtuins: a Chemical Biology Approach. University of Vermont, Burlington, VT, April 2016 (invited talk).

Graham E, Rymarchyk S, Wood M, Zhang K, Lin H, Cen Y. Activity-based Sirtuin Profiling. Clinical and Translational Research Symposium, University of Vermont, Burlington, VT, April 2016 (poster presentation).

Cen Y, Wood M, Fandy T. DNA Hypomethylating Agents Modulate the Activity of the Histone Deacetylase Sirtuin 6 (SIRT6). 2016 AAPS Annual Meeting and Exposition, Denver, CO, November 2016 (poster presentation).

Tran A, French J, Cen Y. Design and Synthesis of Dual-functional Nucleobase Analogs for Labeling Nucleobase Transporters. 2016 ACPHS Student Summer Research Presentation and Award Ceremony, Albany, NY, November 2016 (poster presentation).

Karen Glass
Karen Glass Kim S, Natesan S, Cornilescu G, Carlson S, Tonelli M, McClurg UL, Binda O, Robson CN, Markley JL, Balaz S, Glass KC. Histone Recognition by the ING3 PHD Finger in the TIP60 Histone Acetyltransferase Complex. Sixth Annual ACPHS Research Forum, Albany, NY, January 23, 2016 (Abstract).

Lloyd JT, Gay JC, Carlson SA, Eckenroth BE, Doublie S, Glass KC. Histone Binding and Ligand Recognition by the ATAD2b Bromodomain. Sixth Annual ACPHS Research Forum, Albany, NY, January 23, 2016 (Poster Presentation).

Gay JC, Carlson SA, Glass KC. Using Isothermal Calorimetry to Determine ATAD2b Histone Binding Affinities. Sixth Annual ACPHS Research Forum, Albany, NY, January 23, 2016 (Poster Presentation).

Kim S, Natesan S, Cornilescu G, Carlson S, Tonelli M, McClurg UL, Binda O, Robson CN, Markley JL, Balaz S, Glass KC. Mechanism of Histone H3K4me3 Recognition by the Plant Homeodomain of Inhibitor of Growth 3. Keystone Symposium on Chromatin and Epigenetics, Whistler, BC, Canada, March 21, 2016 (poster presentation).

Kim S, Natesan S, Cornilescu G, Carlson S, Tonelli M, McClurg UL, Binda O, Robson CN, Markley JL, Balaz S, Glass KC. Mechanism of Histone H3K4me3 Recognition by the Plant Homeodomain of Inhibitor of Growth 3. University of Vermont Cancer Center Clinical and Translational Research Symposium, Burlington, VT, April 29, 2016 (poster presentation).

HaiAn Zheng
Zheng HA, Teng J, Feinberg D. Teaching a Regulatory Science Course Blended with eLearning Lectures and Active Learning. AAPS Annual Meeting, San Diego, CA, November 13-17, 2016.

Hawke RL, Pereira HA, Allen DD, O'Barr SA, Poloyac S, Tropsha A, Zheng HA. Trends & Transformations within Graduate Education. AACP Annual Meeting, Anaheim, CA, July 23, 2016  (forum organizer/chair).

Zheng HA. China-US Clinical Pharmacy Experiential Education Exchange (CPEEE) Programs – Achievements, Challenges & Promises. Fudan University School of Pharmacy, Shanghai, May 28, 2016 (invited speaker).

Mall I, Zheng HA, Musteata FM. Investigating transdermal diffusion of vitamin D and 25-hydroxyvitamin D. AAPS-NERDG Annual Meeting, Farmington, CT, April 2016.

Marcel Musteata
Mall I, Zheng HA, Musteata FM. Investigating transdermal diffusion of vitamin D and 25-hydroxyvitamin D. Pittcon 2016, Atlanta, GA, March 2016 and AAPS-NERDG, Farmington, CT, April 2016 (poster presentation).

2015 scholarly activity report

The activities listed below are by members of the Department of Pharmaceutical Sciences on the Albany Campus and span the period from January 1, 2015 - December 31, 2015.

publications

PEER REVIEWED ARTICLES

Stefan Balaz
Balaz S. Response to "Comment on 'Structural Determinants of Drug Partitioning in Surrogates of Phosphatidylcholine Bilayer Strata.'" Molecular Pharmaceutics 2015, 12, 1330–1334.

Yana Cen
Patel J, Huynh MT, Sowers ML, Theruvathu JA, Zhang K, Sowers LC, Cen Y. Synthesis and characterization of pyrimidine 2’-deoxynucleoside monophosphates as biomarkers of DNA damage and enzymatic modification, Analytical Biochemistry (accepted).

Karen Glass
Kim S, Natesan S, Cornilescu G, Carlson S, Tonelli M, McClurg UL, Binda O, Robson CN, Markley JL, Balaz S, Glass KC. Mechanism of Histone H3K4me3 recognition by the plant homeodomain of inhibitor of Growth 3. Journal of Biological Chemistry (in revision).

William Millington
Feleder C, Yilmaz MS, Peng J, Göktalay G, Millington WR. The OVLT initiates the fall in arterial pressure evoked by high dose lipopolysaccharide: Evidence that dichotomous, dose-related mechanisms mediate endotoxic hypotension. Journal of Neuroimmunology, Aug 2015, 285:94-100.

Millington WR, Yilmaz MS, Feleder C. The initial fall in arterial pressure evoked by endotoxin is mediated by the ventrolateral periaqueductal gray. Clinical and Experimental Pharmacology and Physiology (Submitted: In Revision).

Basaran NF, Buyukuysal LR, Yilmaz, SM Aydin S, Cavun S, Millington WR. The effect of Gly-Gln [ß-endorphine30-31] on morphine-evoked serotonin and GABA efflux in the nucleus accumbens of conscious rats. Neuropeptides (In Press).

Göktalay G, Millington WR. Hypovolemic hemorrhage induces Fos expression in the rat hypothalamus: Evidence for involvement of the lateral hypothalamus in the decompensatory phase of hemorrhage. Neuroscience (In Press).

Musteata FM, Sandoval M, Ruiz JM, Harrison K, McKenna D, Millington W. Evaluation of in vivo solid phase microextraction for minimally invasive analysis of nonvolatile phytochemicals in Amazonian plants. Analytica Chimica Acta (In Review).

Marcel Musteata
LaPorte B, Musteata FM. Fluidic device for generating pharmacokinetic profiles matching preset parameters. Journal of Pharmaceutical Innovation, 10(3), 222-232, 2015.

Donabella P, Rogers N, Levin R, Musteata FM. Development of supported liquid phase microextraction probes for in vivo pharmacokinetic studies. Bioanalysis, Vol. 7(6), p. 661-670, DOI 10.4155/bio.15.7, 2015.

Alsaqr A, Rasoully M, and Musteata FM. Investigating transdermal delivery of vitamin D3. AAPS PharmSciTech, 16(4), DOI 10.1208/s12249-015-0291-3, 2015.

Mason D, Donabella P, Nnani D, Musteata FM. Normalized vitamin D metabolite concentrations are better correlated to pharmacological effects than measured concentrations. Future Science OA, FSO83 doi: 10.4155/FSO.15.83, 2015.

Musteata FM, Sandoval M, Ruiz JM, Harrison K, McKenna D, Millington WR. Evaluation of in vivo solid phase microextraction for minimally invasive analysis of nonvolatile phytochemicals in Amazonian plants. Analytica Chimica Acta (In Review).

HaiAn Zheng
Zheng HA, Truong J, Carroll F, Pai MP. Do formulation differences between reference listed drug and generic products of piperacillin-tazobactam impact reconstitution? Antimicrobial Agents and Chemotherapy, 59 (3) 1767-1769, 2015.

BOOK CHAPTERS

El-Fawal, HAN. “Court Systems” in Encyclopedia of Forensic and Legal Medicine. Payne-James J, Byard R, Corey T, Henderson C, eds., 2nd Edition, Volume 2, pp. 662–672, Elsevier Publishing, London, UK, 2016.

El-Fawal, HAN. “Judicial Punishment” in Encyclopedia of Forensic and Legal Medicine. Payne-James J, Byard R, Corey T, Henderson C, eds., 2nd Edition, Volume 3, pp. 282–290, Elsevier Publishing, London, UK, 2016.

El-Fawal HAN, Rembisz P, Alobaidi R, Mousa, SA. “Chemotherapy-mediated pain and peripheral neuropathy: Impact of oxidative stress and inflammation” in Oxidative Damage and Antioxidant Imbalance: The Science of Biology in Health and Disease. Armstrong F, Stratton RD, eds., pp: 367-388, John Wiley & Sons, Inc., 2016.

El-Fawal, HAN. “The Tree and the Forest: A Need for Dialogue and a Collaborative Approach in the Safety of Nanomedicines” in Handbook of Clinical Nanomedicine Volume II: Law, Business, Regulation, Safety and Risk. Bawa R (Editor), Audette GF and Reese BE (Assistant Editors), Pan Stanford Publishing, Singapore, 2016.

HaiAn Zheng
Wu L, Smith H, Zheng HA, Yu L. Drug Product Approval in the United States and International Harmonization, Developing Oral Solid Dosage Forms. Academic Press, in press (book chapter co-author).

Zheng, HA. Intravenous Infusion, Applied Biopharmaceutics and Pharmacokinetics, 7th Edition. Leon Shargel and Andrew Yu, eds., McGraw-Hill, September 4, 2015 (chapter editor).

CONFERENCES AND PRESENTATIONS

Stefan Balaz
STEM Saves Lives and Creates Jobs. Vermont Biosciences Alliance, Burlington, VT, April 13, 2015 (panelist).

Yana Cen
Cen Y, Zhang K, Lin H. Activity-based photoaffinity labeling of sirtuins. 5th Annual ACPHS Research Forum, Albany, NY, January 24, 2015. Cen Y, Zhang K, Lin H. Development of activity-based chemical probes for sirtuin profiling. Epigenomics and Novel Therapeutic Targets Conference, Boston, MA, May 2015.

Richard Dearborn, Jr.
Ainsworth M, Voigt JM, Dearborn Jr. RE. Hedgehog-dependent regulation of the VDUP1 tumor suppressor in Drosophila: Developmental and promoter analyses. AAPS Conference, Farmington, CT, April 16, 2015 (abstract).

Karen Glass
Carr F, Glass KC, and Gray J. Epigenetic Signaling and Breast Cancer. Invited talk for panel session on Environmental Endocrine Disruptors and Their Impact on Weight, Metabolism, and Cancer, The 18th Annual Women's Health and Breast Cancer Conference, Burlington, VT, Oct 2, 2015.

Glass KC, Lubula MY, Poplawski A, Carlson S, Eckenroth BE, Hu K, Lee W, Peng D, Chruszcz M, Shi X, Markley JL. Molecular basis of histone acetyllysine recognition by the BRPF1 bromodomain. 5th Annual ACPHS Research Forum, Albany, NY, January 24, 2015.

Carlson S, Lubula MY, Eckenroth BE, Poplawski P, Neuhardt E, Glass KC. Epigenetic roles of the MOZ histone acetyltransferase complex. Keystone Symposia on Epigenetics and Cancer, Keystone, CO, Jan 26, 2015.

Glass KC, Lubula MY, Poplawski A, Carlson S, Eckenroth BE, Hu K, Lee W, Peng D, Chruszcz M, Shi X, Markley JL. Molecular Basis of Histone Acetyllysine Recognition by the BRPF1 Bromodomain. Keystone Symposia on Epigenetics and Cancer, Keystone, CO, Jan 26, 2015.

Glass KC. Molecular basis of histone recognition by the MOZ HAT complex. Epigenomics and Novel Therapeutic Targets, Boston, MA, 2015 (invited talk and session chair of Transcriptional Regulation).

Glass KC. Round Table discussion, Vermont Genetics Network Career Day, Burlington, VT, April 15, 2015.

Marcel Musteata
LaPorte B, Musteata FM. Desktop RAT for generating in vitro pharmacokinetic profiles. Pittcon 2015, New Orleans, LA, March 2015 (oral presentation).

LaPorte B, Musteata FM. 4D-Printed Pharmacokinetic Profiles in Teaching and Research. AAPS-NERDG, Farmington, CT, April 2015 (poster presentation).

HaiAn Zheng
Zheng HA. Regulatory Science and Botanical Drug Products – Quality for Safety. China-America Herbal Safety Symposium, Shanghai, JiaoTong University Affiliated Tongren Hospital, October 5, 2015 (invited talk).

Cai W, Zheng HA, DiLorenzo J, Briceland LL, Hou A. A China-US exchange program for clinical pharmacy experiential education: A 6-Year Report. AACP Annual Meeting, National Harbor, MD, July 11-14, 2015.

Zheng, HA. Regulatory science for botanicals and biologicals – Something old and something new. Fudan University School of Pharmacy, June 25, 2015 (invited talk).

Cha W, Park K, Zheng HA. Exploring the binding interface between human leptin and leptin receptor. AAPS Northeast Regional Annual Meeting, Hartford, CT, April, 16, 2015.