Stefan Balaz, Ph.D., D.Sc.

Bio: 

Education

Ph.D. and D.Sc., Comenius University, Bratislava, Slovakia
M.S., Slovak University of Technology, Bratislava, Slovakia

research interests

The overall, long-term goal is to contribute to the understanding of processes affecting the fates and effects of drugs in the body, in terms of structures and properties of drugs and body components, by a concerted deployment of bench-top and computational techniques. The approaches can be divided into two main streams: Subcellular Pharmacokinetics and Drug-Receptor Interactions, which are integrated into Quantitative Structure-Time-Activity Relationships.

Click the following link to learn more about Dr. Balaz' research lab.

Selected Publications

Balaz S: Modeling kinetics of subcellular disposition of chemicals. Chem Rev 2009; 109: 1793-1899.

Zhang Y, Lukacova V, Bartus V, Sun G, Manivannan E, Ghorpade SR, Jin X, Manyem S, Sibi MP, Cook GR and Balaz S: Binding of matrix metalloproteinase inhibitors to extracellular matrix: 3D-QSAR Analysis. Chem Biol Drug Des 2008; 72: 237-248.

Khandelwal A, Balaz S: QM/MM Linear Response method distinguishes ligand binding affinities for closely related metalloproteins. Proteins 2007; 69: 326-339.

Khandelwal A, Balaz, S: Improved estimation of ligand-macromolecule affinities by a Linear Response approach using a combination of multi-mode MD simulation and QM-MM methods, J Comp Aid Mol Des 2007; 21: 131-137.

Zhang Y, Lukacova V, Bartus V, Balaz S: Structural determinants of binding of aromates to ECM: A multi-species multi-mode CoMFA study. Chem Res Toxico 2007; 20: 11-19.

Lukacova V, Peng M, Fanucci G, Hinderliter A, Cook GR, Balaz S: Drug-membrane interactions studied in phospholipid monolayers adsorbed on nonporous alkylated microspheres. J Biomol Screen 2007; 12: 186-202.

Lukacova V, Peng M, Tandlich R, Hinderliter A, Balaz S: Partitioning of organic compounds in phases imitating headgroup and core regions of phospholipid bilayers. Langmuir 2006; 22: 1869-1874.

Lukacova V, Zhang Y, Kroll DM, Raha S, Comez D, Balaz S. A comparison of the binding sites of MMPss and TNF-alpha converting enzyme. J Med Chem 2005; 48: 2361-2370.

Khandelwal A, Lukacova V, Kroll OM, Comez 0, Raha S, Balaz S: A combination of docking, QM/MM, and MD simulation for binding affinity estimation of metalloprotein ligands. J Med Chem 2005; 48: 5437-5447

Chair
Professor
Department of Pharmaceutical Sciences - Vermont Campus