Karen C. Glass, Ph.D.

Bio: 

Education

Ph.D., Microbiology & Molecular Genetics, University of Vermont, Burlington, VT (Advisor- Dr. Christopher S. Francklyn)
B.S.,  Microbiology, University of Massachusetts, Amherst, MA (Advisor- Dr. Steven J. Sandler)

Courses Taught at ACPHS

Infectious Disease
Cardiovascular PTPM
Principles of Pharmacology and Medicinal Chemistry 

Research Interests

Dr. Glass's research focuses on understanding the molecular mechanisms underlying chromatin dynamics and its role in the regulation of diverse cellular process including gene transcription and replication. Click here to learn more about Dr. Glass' research.

Research Grants

R15GM104865 (Glass, KC), 1/13 - 12/15
National Institute of General Medical Sciences of the National Institutes of Health
"A unique double PHD finger and bromodomain in epigenetic signaling"

10BGIA3420014 (Glass, KC),  7/10-6/12
American Heart Association PMA Beginning Grant-in-Aid
“The Structural Role of PHD Finger Domains in Chromatin Remodeling”

F32 GM083462 (Champagne, KS), 7/08-8/10
National Research Service Award, postdoctoral fellowship
“The Structural Role of PHD Finger Domains in Chromatin Remodeling”

08-049-01-GMC (Champagne, KS) (Terminated on 6/30/2008), 01/08-12/10
American Cancer Society, postdoctoral fellowship
“The Structural Role of PHD Finger Domains in Chromatin Remodeling” 

Vermont DOE EPSCoR graduate research fellowship. 2001-2003.

Howard Hughes grant for undergraduate research. 1999. 

Honors Research Grant for undergraduate thesis research. 1998.

Selected Publications/Conference presentations

(Please note name change in 2009 from Champagne KS to Glass KC).

Avvakumov, N, Lalonde, ME, Saksouk, N, Landry, AJ, Paquet, E, Glass, KC, Ullah, M, Doyon, Y, Cayrou, C, Robitaille, G, Côté, V, Richard, D, Yang, XJ, Kutateladze, TG and Côté, J. Conserved Molecular Interactions Within Myst-ING Acetyltransferase Complexes That Regulate Cell Proliferation (submitted February 2011).

Hom, RA, Chang, PY, Roy, S*, Musselman, CA*, Glass, KC*, Selezneva, AI, Gozani, O, Ismagilov, RF, Cleary, MI and Kutateladze, TG. (2010) Molecular mechanism of MLL PHD3 and RNA recognition by the Cyp33 RRM domain. J Mol Biol. Jul 9;400(2):145-54. *These authors contributed equally to the work.

Roy S, Musselman CA, Kachirskaia I, Hayashi R, Glass KC, Nix JC, Gozani O, Appella E, Kutateladze TG.  (2010) Structural insight into p53 recognition by the 53BP1 tandem Tudor domain.  J Mol Biol. 14;398(4):489-96.

Champagne KS and Kutateladze TG.  (2009) Structural insight into histone recognition by the ING PHD fingers. Current Drug Targets. 10:432-41.

Hung T*, Binda O*, Champagne KS*, Kuo AJ, Johnson K, Chang HY, Simon MD, Kutateladze TG and Gozani O.  (2009) ING4-mediated crosstalk between histone H3K4 trimethylation and H3 acetylation attenuates cellular transformation. Mol Cell. 33:248-256. *These authors contributed equally to the work.

Saksouk N, Avvakumov N*, Champagne KS*, Hung T*, Doyon Y, Cayrou C, Paquet E, Ulla M, Landry AJ, Côté V, Yang XJ, Gozani O, Kutateladze TG and Côté J.  (2009) HBO1 HAT complexes target chromatin throughout gene coding regions via multiple PHD finger interactions with histone H3 tail.  Mol Cell. 33:257-265. *These authors contributed equally to the work.

Champagne KS, Saksouk N, Peña PV, Johnson K, Ullah M, Yang XJ, Côté J, Kutateladze TG. (2008) The crystal structure of the ING5 PHD finger in complex with an H3K4me3 histone peptide.  Proteins. 72: 1371-6.

Peña PV, Hom RA, Hung T, Lin H, Kuo AJ, Wong RP, Subach OM, Champagne KS, Zhao R, Verkhusha VV, Li G, Gozani O, Kutateladze TG. (2008) Histone H3K4me3 binding is required for the DNA repair and apoptotic activities of ING1 tumor suppressor.  J. Mol. Biol. 380: 303-12.

Matthews AG, Kuo AJ, Ramón-Maiques S, Han S, Champagne KS, Ivanov D, Gallardo M, Carney D, Cheung P, Ciccone DN, Walter KL, Utz PJ, Shi Y, Kutateladze TG, Yang W, Gozani O, Oettinger MA. (2007) RAG2 PHD finger couples histone H3 lysine 4 trimethylation with V(D)J recombination. Nature. Dec 13; 450 (7172): 1106-10.

Champagne KS, Piscitelli E, Francklyn CS. (2006) Substrate recognition by the hetero-octameric ATP phosphoribosyltransferase from L. lactis. Biochemistry 45:14933-43.

Champagne KS, Sissler M, Larrabee Y, Doublié S, Francklyn CS. (2005) Activation of the hetero-octameric ATP phosphoribosyl transferase through subunit interface rearrangement by a tRNA synthetase paralog.  J. Biol. Chem.  280: 34096-34104.

Bovee ML, Champagne KS, Demeler B, Francklyn CS. (2002) The Quaternary Structure of the HisZ-HisG N-1-(5’-Phosphoribosyl)-ATP Transferase from Lactococcus lactis.  Biochemistry.  41: 11838-11846.

Conference Presentations

Histone Deacetylases & Reversible Acetylation In Signaling & Disease. FASEB conference, (2011), Steamboat Springs, CO.“The role of ING4 and ING5 tumor suppressors in chromatin remodeling and disease.” Short talk selected from abstracts.

Department of Pharmaceutical Sciences (2010). Albany College of Pharmacy and Health Sciences (Vermont Campus), Colchester, VT. "Structural Insights into the Role of PHD Fingers in Epigenetics and Disease."

Department of Pharmacology, Postdoctoral Summer Seminar Series. (2009) UC Denver, Aurora, CO. "The role PHD fingers in chromatin remodeling and disease."

Department of Pharmacology, Postdoctoral Summer Seminar Series. (2008) UC Denver, Aurora, CO. "The role PHD fingers in chromatin remodeling and disease."

Department of Biomolecular Structure (2008) UC Denver, Aurora, CO. “The role of ING4 and ING5 tumor suppressors in chromatin remodeling.”

Department of Pharmacology, Postdoctoral Summer Seminar Series. (2007) UCHSC, Aurora, CO. "The role of ING4 and ING5 tumor suppressors in chromatin remodeling."

International Conference on Aminoacyl-tRNA Synthetases: Ancient Molecules for Future Biology and Medicine. (2004) Seoul National University, Seoul, Korea. “A Histidyl-tRNA Synthetase Paralog with a Role in Histidine Biosynthesis.”

Ribo Club, Faculte de Medecine, Universite de Sherbrooke, Sherbrooke, QC, Canada. (2004) “A Histidyl-tRNA Synthetase-like Domain Involved in the Regulation of ATP-Phosphoribosyl Transferase from Lactococcus lactis.”

Structural Biology Supergroup, Seminar Series. (2004) UVM, Burlington, VT. “The Macromolecular Structure of ATP-Phosphoribosyl Transferase from Lactococcus lactis:  Implications for Regulation by a Histidyl-tRNA Synthetase Paralog.”

VT DOE EPSCoR Retreat. (2002) Burlington, VT.  “Structural Studies on an ATP Phosphoribosyl Transferase from Lactococcus lactis.”

American Crystallography Association, annual conference. (2001) Los Angeles, CA.  "Structural Studies of an ATP-Phosphoribosyl Transferase from Lactococcus lactis."

Honors and Achievements

Poster presentation award winner in the Faculty/Staff category. Vermont Cancer Center's Clinical and Translational Research Symposium: Inflammation & Cancer. 2010.
Poster presentation award. University of Colorado Denver Postdoctoral Research Day. 2010.
Post-Doctoral Award for Outstanding Achievement, Department of Pharmacology, University of Colorado Denver (UC Denver), School of Medicine. 2008.
Keystone Symposia Scholarship, ‘Molecular Basis for Chromatin Modifications and Epigenetic Phenomena’, Snowmass, CO. 2008.
American Heart Association, postdoctoral fellowship (declined). 2008.
Travel award from the University of Vermont (UVM) graduate college for a tRNA Synthetase conference, Seoul, Korea. 2004.
American Crystallography Association student travel grant, ACA meeting, Los Angeles, CA. 2001.
Graduated with honors, Magna Cum Laude. 1999.
Golden Key National Honors Society, member. 1997.
Alpha Lambda Delta, a national academic honors society for freshmen in the top 10% of their class, member. 1996.

Previous Positions or Appointments

08/11-present - Adjunct Assistant Professor, Department of Biochemistry, University of Vermont, College of Medicine, Burlington, VT

11/06-8/10 - Postdoctoral Research Fellow, Advisor- Dr. Tatiana G. Kutateladze, University of Colorado at Denver, Aurora, CO

11/05-11/06 - Postdoctoral Research Fellow, Advisor- Dr. Harry F. Noller, University of California Santa Cruz, Santa Cruz, CA

06/98-08/98 - Summer Undergraduate Research Student, Advisor- Dr. Jeffrey P. Bond, University of Vermont, Burlington, VT

Affiliate Professor

Introduction to General Biology for Majors, Metropolitan State College of Denver. Course number Biol 1080. Advisor- Dr. Fordyce Lux III, Chair, Department of Biology, MSCD. 2010.

Professional Organization Memberships

2011-present Member, American Crystallography Association
2009-present Member, National Postdoctoral Association
2007-present Member, Colorado Bioscience Association

ACPHS Committees

2010-present Interviewing for ACPHS PharmD Class of 2015.
2010-present student advisor for six PharmD candidates (Class of 2014) at ACPHS- Vermont.
2010/2011 Cloaker at the ACPHS- Vermont Campus White Coat Ceremony

Assistant Professor
Department of Pharmaceutical Sciences - Vermont Campus