Hassan A.N. El-Fawal, Ph.D.

Bio: 

Education

  • Ph. D., Virginia Polytechnic Institute and State University (Virginia Tech)
  • M. Sc., University of Guelph, Canada
  • B. Sc., University of Alexandria, Egypt

Teaching Experience

Natural Sciences

  • General Biology; General Chemistry; Geology; Ecology and Environmental Science

Biomedical Sciences 

  • Anatomy and Medical Physiology (with and without cadaver); Applied Biochemistry; Immunology; Neurobiology; Clinical Neuroscience; Pathophysiology; Pharmacology; Systemic and Molecular Toxicology; Research Methods and Statistics; Environmental Medicine; Biomarkers; Toxicogenomics; Nanotoxicology 

Humanities 

  • Near Eastern History and Religion; Arabic

Research Interests

Dr. El-Fawal’s Neurotoxicology Laboratory focuses on nervous system insult and neurodegenerative diseases of toxic, genomic and sporadic etiologies. In particular, interactions between nervous and immune systems, with the hope of developing and validation of biomarkers of neurotoxic effects is a major emphasis. In a parallel vein, the laboratory is exploring the nervous system toxicity of ambient ultrafine particles and man-made nanoparticles, as well as the use of nanoformulations to ameliorate the toxicity of anti-neoplastic pharmaceuticals. Finally, the laboratory has been pioneering exploration of the role of angiogenesis in non-cancer endpoints, including developmental neurotoxicity.

Selected Publications

Book Chapters and Reviews

El-Fawal, HAN (2016). The Tree and the Forest: A Need for Dialogue and a Collaborative Approach in the Safety of Nanomedicines. In Handbook of Clinical Nanomedicine Volume II: Law, Business, Regulation, Safety and Risk. R. Bawa, G. F. Audette and B. E. Reese (Eds), pp: 1281-1289. Pan Stanford Publishing, Singapore.

El-Fawal, HAN, Rembisz P, Alobaidi R, Mousa SA. (2016). Chemotherapy-mediated pain and peripheral neuropathy: Impact of oxidative stress and inflammation. In Oxidative damage and antioxidant imbalance:  The science of biology in health and disease. First ed., D. Armstrong and R. D. Stratton. pp 367-388. John Wiley & Sons, Inc.

El-Fawal, HAN. (2016). Court Systems. In Encyclopedia of Forensic and Legal Medicine (J. Payne-James, R. Byard, T. Corey and C. Henderson, eds). Second ed; Vol. 1, pp. 662-672. Oxford: Elsevier.

El-Fawal, HAN. (2016). Judicial Punishment. In Encyclopedia of Forensic and Legal Medicine (J. Payne-James, R. Byard, T. Corey and C. Henderson, eds). Second ed; Vol. 3, pp. 282-290. Oxford: Elsevier.

Yasin BR, El-Fawal HAN, Mousa SA. (2015). Date (Phoenix dactylifera) Polyphenolics and Other Bioactive Compounds: A Traditional Islamic Remedy's Potential in Prevention of Cell Damage, Cancer Therapeutics and Beyond. Int J Mol Sci. 17;16(12):30075-90. doi: 10.3390/ijms161226210.  

El-Fawal, HAN. (2014). Neuroantibody (NAb) biomarkers: links and challenges in environmental neurodegeneration and autoimmunity. Autoimmune Disease 2014 2014:340875. doi: 10.1155/2014/340875.

El-Fawal, HAN. (2011). Neurotoxicology. In: Nriagu JO (ed.) Encyclopedia of Environmental Health, First edition, volume 4, pp. 87–106: Elsevier.

Articles

Al-sofiani M, Aljammah A, Hasanato A, Racz M, Mason D, El-Fawal HAN, Mousa SA. (2015). Effect of vitamin D supplementation on glucose control and inflammatory response in type 2 diabetes: Double blind, randomized clinical trial. Intl J.  Endocrin. Metab. 10;13(1):e22604. 

Osuna CE, Grandjean P, Weihe P, El-Fawal HAN. (2014). Autoantibodies associated with prenatal and childhood exposure to environmental chemicals in Faroese children. Toxicol Sci. 142(1):158-166.  

Al-Amri WS, Balachandran I, Thangirala, S, Coleman, A, El-Fawal, HAN, Mousa, SA. (2013). Differential association between HER2/neu and angiogenesis in breast cancer. Am J Cancer Biol 2013; 1: 201300207,15.

Johnson, A, El-Fawal, H.A. N., Mason, D. (2013). Neurobiomarkers and Environmental Factors in CKD and HD. Renal Research Institute Dialysis Times 20 (2). 

Pai, M., Chen, W., Garba, A., Cui, H., Zaffo, B., El-Fawal, H.A.N. and Mousa, S. (2013). A novel preclinical pharmacokinetic and toxicology model to evaluate antimicrobial-induced acute kidney injury across weight and sex. Antimicrobial Agents and Chemotherapy 57:716-722. 

Mason, D.L, Assimon, M.M., Bishop, J. R. and El-Fawal, H.A.N. (2013). Nervous system autoantibodies and vitamin D receptor gene polymorphisms in hemodialysis patients. Hemodialysis International 17:237-242.

Assimon, M.M., Salenger, P.V., El-Fawal, H.A.N. and Mason, D.L. (2012). Nutritional vitamin D supplementation in hemodialysis: a potential vascular benefit? Nephrology 17:3-11.

El-Fawal HAN, McCain W. (2008). Monitoring the development of organophosphorus-induced delayed neuropathy (OPIDN) and its amelioration. Neurotoxicol. Teratol 30: 161-166, 2008.

El-Fawal, HAN, O’Callaghan JP. (2008). Autoantibodies to neurotypic and gliotypic proteins; Assessment of trimethyltin. Neurotoxicol 9:109-115. 

Surendran G, El-Fawal HAN. (2008). Neuroimmune responses to toxic agents: Comparison of organometal electrophiles using detection of antibodies to neural cytoskeleton and myelin as biomarkers. J Pharmacol Toxicol 3: 173-189.

Recent Selected Presentations 

Alobaidi R, Thangirala S, Mousa SA, El-Fawal, HA (2016). Small Molecule OT-404 Inhibits Oxidative Stress (OS) And NFκB Providing Protection In Cisplatin-Induced Peripheral Neuropathy (CIPN). Society of Toxicology.

El-Fawal HA, Abdel Moneim I, El-Gazzar RM, Shamy MY (2016). Neuroantibodies (NAb) In Males With Mercury (Hg) Exposure: Prevalence And Association With Clinical Signs. Society of Toxicology.

El-Fawal, HA (2015).  Neurotoxic and Autoimmune Potential of Nanoparticles: Aggravation to Amelioration.  First International Nanomedicine Symposium and Workshop, ACPHS, August 3-7.

Sardar, J, Mason, D, El-Fawal HA (2015). Association of autoantibodies to nervous system (NS) proteins (NAb) with demographics in hemodialysis (HD) patients. American Association of Pharmaceutical Sciences (AAPS) Regional Meeting.

Cichewicz A, Mason D, Hudgens E, Gallagher JE.  El-Fawal HAN. (2015). Association of neuroantibodies (NAB) with glutathione-S-transferase (GST) isozyme polymorphisms (SNP) in African-American children with metal exposures. Society of Toxicology. 

Dougherty K, Cichewicz A, Hudgens E, Gallagher JE, El-Fawal HAN. (2015). Neuroantibodies (NAB) in African-American (AA) children with metal exposures associate with cytokine and human leukocyte antigen (HLA) polymorphisms (SNP). Society of Toxicology. 

Monaco-Brown M, Price D, Horgan M. and El-Fawal, H.A.N. (2015).  Translational utility of neuroantibody (NAb) biomarkers in hypoxic-ischemic encephalopathy (HIE). Pediatric Academic Societies Annual Conference, San Diego, CA.

Alnamnakani M, Mousa, SA, El-Fawal, HAN. (2014). Thyromimetic Effects of Araclor 1254 (AR) and Polybrominated Diether 100 (PBDE) on Angiogenesis (AG) Are Mediated via the αVβ3 Integrin Receptor. Society of Toxicology.

Cichewicz A, Hudgens E, Gallagher JE, El-Fawal, HAN. (2014). Neuroantibodies (NAB) in African-American Children: Associations with Gender, Gluthathione-S-Transferase (GST) Pi Polymorphisms (SNP) and Heavy Metals. Society of Toxicology.

El-Fawal, HAN, Johnson A, Storrs P, Bishop J, Elnagar K, Mason D. (2014). Prevalence and Titers of Neuroantibodies (NAb) in Hemodialysis Patients (HD): Associations with Vitamin D Receptor (VDR) Polymorphisms (SNP) and Blood Lead (BPb). Society of Toxicology.

Mason D, El-Fawal, HAN. (2014). Association of Neuroantibodies (NAb), Lead (Pb), Vascular, and Inflammatory Biomarkers in Hemodialysis Patients (HD). Society of Toxicology.

Shaiba, LA, Horgan M, Mousa, SA and El-Fawal, HA (2013). Proteomic and neuroimmune biomarkers of hypoxic-ischemic encephalopathy (HIE) in an experimental model. Pediatric Academic Societies Annual Conference, Washington DC.

Shaiba, LA, O’Callaghan, JP and El-Fawal, HA (2013). Glial fibrillary acidic protein (GFAP) and anti-glial antibody biomarkers in an experimental model of hypoxic-ischemic encephalopathy (HIE). Pediatric Academic Societies Annual Conference, Washington DC.

Shaiba, LA, Mousa, SA and El-Fawal, HA. (2012). Biphasic effects of lead on angiogenesis (AG): Implications for developmental neurotoxicity. Society of Toxicology.

Shaiba, LA, Alrowaily, NF, Zaffo, BJ, Mousa, SA, El-Fawal, HA. (2011). Abnormal induction of angiogenesis (AG) by inorganic lead (Pb): Implications for developmental neurotoxicity and acute encephalopathy. Proceedings Joint Meeting of the Pediatric Academic Societies and the Asian Pediatric Research Society. Denver, CO. 

Alrowaily, NF, Shaiba, LA, Zaffo, BJ, Mousa, SA, El-Fawal, HA. (2011). Differential effects of neurotoxic heavy metals on tumor-induced angiogenesis (AG). Proceedings Joint Meeting of the Pediatric Academic Societies and the Asian Pediatric Research Society. Denver, CO.

PROFESSIONAL ORGANIZATIONS

  • Society of Toxicology - Neurotoxicology, Nanotoxicology and Biotechnology Specialty Sections
  • Society for Experimental Biology and Medicine - Editorial Board in Bio-nanoscience Section

INSTITUTIONAL COMMITTEES at Acphs

  • Chair, Institutional Review Board
  • Vice-Chair, Institutional Animal Care and Use Committee 
Professor
Department of Pharmaceutical Sciences - Albany Campus