Patricia G. Phillips, Ph.D.

Education

Postdoctoral Fellow Physiology, Albany Medical College, Albany, NY
Ph.D. Biochemistry, W. Virginia Univ., Morgantown, WV
M.S. Biochemistry, W. Virginia Univ., Morgantown, WV 
B.A. Chemistry, Marywood College, Scranton, PA

Research InterestS

Endothelial and tumor cell interactions, medical applications of nanotechnology, roles of cytoskeleton and extracellular matrix in angiogenesis, endothelial permeability in acute lung injury.

Selected Publications

Phillips PG, Birnby L, DiBernardo LA, Ryan TJ, Tsan M-F. (1992) Hyperoxia increases plasminogen activator activity of cultured endothelial cells. Am. J. Physiol. (Lung Cell. Molec. Physiol.6) L21-L31.

Partridge CA, CJ Horvath, TJ Del Vecchio, PG Phillips, AB Malik. (1992) Influence of extracellular matrix in tumor necrosis factor-induced increase in extracellular matrix. Am. J. Physiol. 263 (Lung Cell. Molec. Physiol. 7):L627-L633

Ferro TJ, DM Parker, LM Commins, PG Phillips, A Johnson. (1993) Tumor necrosis factor-a activates pulmonary artery endothelial protein kinase C. Am. J Physiol. 264: L7-L14.

Phillips PG, LM Birnby. (1995) Hypoxia induces capillary network formation in cultured bovine pulmonary microvessel endothelial cells (PMVEC). Am. J. Physiol. 268: L788-L800.

Partridge CA, PG Phillips, MJ Niedbala, JJ Jeffrey. (1997) Localization and activation of type IV collagenase/gelatinase at endothelial focal contacts Am. J. Physiol. 272:L813-L822.

Phillips PG, Birnby LM, Narendran A, Milonovich WL. (2001) Nitric oxide modulates capillary formation at the endothelial cell-tumor cell interface. Am J. Physiol 281(1):278-290.

Phillips PG, L Birnby (2004) Nitric oxide modulates Caveolin-1 (Cav-1) and MMP-9 expression and distribution at the endothelial cell/tumor cell interface. Am. J. Physiol Am. J. Physiol. Lung Cell Mol. Physiol. 286:L1055–1065. (PDF: Phillips MMP9 and caveolin).

Lincoln II, DW, Phillips PG, Bove K. (2003) Estrogen-induced Ets-1 promotes capillary formation in an in vitro  tumor angiogenesis Model. Breast Cancer Research and Treatment, 78:167-178.

Lincoln D, Larsen AM, Phillips PG, Bove K. (2003) Isolation of murine aortic endothelial cells in culture and the effects  of sex steroids on their growth. In Vitro Cell. Dev. Biol. 39:140-145.

Phillips PG, Yalcin M, Cui H, Abdel-Nabi H, Sajjad M, Bernacki R, Veith J, Mousa SA. (2011) Increased tumor uptake of chemotherapeutics and improved chemoresponse by novel non-anticoagulant low molecular weight heparin. Anticancer Res. 31(2):411-9.

Sudha T, Phillips P, Kanaan C, Linhardt RJ, Borsig L, Mousa SA. (2012) Inhibitory effect of non-anticoagulant heparin (S-NACH) on pancreatic cancer cell adhesion and metastasis in human umbilical cord vessel segment and in mouse model. Clin Exp Metastasis. 29(5):431-9.

Book Chapters

Phillips PG, Tsan M-F. Cytoarchitectural aspects of endothelial barrier function in response to oxidants and inflammatory mediators. In: Lung Vascular Injury: Molecular and Cellular Response. A. Johnson (editor). Marcel Dekker Inc., 1992, pp. 113-135.

Phillips PG. Thrombin-induced alterations in endothelial cell cytoarchitecture and functional properties. Seminars in Thrombosis and Hemostasis. 20(4):417-425, 1994.

Phillips PG, Birnby L M, A Narendran, WL Milonovich. Modulation of angiogenesis: experimental strategies and potential therapeutic applications In: Bladder Disease: Research Concepts and Clinical Applications. Edited by A. Atala. New York: Kluwer Academic/Plenum Publisher pp. 803-829, 2003.

Research and Conference Presentations

Phillips PG, Lewis C, Birnby L. Nitric oxide modulates endothelial cell expression/activity of matrix metalloproteinases -2 and -9 in lung carcinoma-induced capillary formation. FASEB J 16(4): A368, 2002.

Phillips PG, Birnby LM. Role of Endothelial Cell (EC) Caveolin-1 (Cav-1) and Matrix Metalloproteinase –9 (MMP-9) in Lung Cancer Cell-induced Capillary Formation in an in vitro Angiogenesis Model. American Assoc. for Cancer Research Conference: New Directions in Angiogenesis Research, October 2003.

Phillips PG and Birnby L. Nitric Oxide (NO) modulates focal proteolysis during capillary formation via effects on matrix metalloproteinase (MMMP)/Caveolin-1 (Cav-1) co-localization in endothelial cells (EC) FASEB J. 17 (4): 251, 2003.

Abstracts/Poster Presentations

Phillips PG, Lewis C, Birnby L. Nitric oxide modulates endothelial cell expression/activity of matrix metalloproteinases -2 and -9 in lung carcinoma-induced capillary formation. FASEB J 16(4): A368, 2002.

Phillips PG and Birnby L. Nitric Oxide (NO) modulates focal proteolysis during capillary formation via effects on matrix metalloproteinase (MMMP)/Caveolin-1 (Cav-1) co-localization in endothelial cells (EC). FASEB J. 17 (4): 251, 2003.

Phillips PG, L Birnby. Role of Endothelial Cell (EC) Caveolin-1 (Cav-1) and Matrix Metalloproteinase –9 (MMP-9) in Lung Cancer Cell-induced Capillary Formation in an in vitro Angiogenesis Model. Presented at American Assoc. for Cancer Research Meeting: New Directions in Angiogenesis Research, October 2003.

Mousa SA, D Bharali, L Borsig, E Dier, S Mousa, M Yalcin, P Phillips. Site-directed delivery of chemotherapy and non-anticoagulant sulfated heparin in breast cancer. ASCO Annual Meeting, Baltimore MD, 2008.

Phillips PG, M Yalcin, H H Abdel-Nabi, M Sajjad, R Bernacki, SA Mousa. Effects of novel heparin-derived compounds on tumor uptake of chemotherapeutics and chemoresponse. ASCO Annual Meeting Orlando FL, 2009.

Awards

  • American Heart Assoc. Grant-in-Aid 
  • VA Merit Review Award 
  • American Heart Assoc. Grant-in-Aid 
  • NIH RO-1 Grant 
  • VA Merit Review Award 
  • VA Merit Review Award 
  • NIH 1R43EY016268-01A1 
  • NIH 1R43EY017222-01 
  • NIH 1R43CA121636-01A1

PROFESSIONAL ORGANIZATIONS

  • American Physiological Society
  • American Society for Cell Biology
  • American Heart Association Cardiopulmonary and Basic Science Councils

COMMITTEE PARTICIPATION

  • VA Research Biosafety Committee (Chair) 1990-2004 
  • VA R&D Committee 1992-2001, Chair, 1998-1999 
  • VA Merit Review Surgery Study Section (ad hoc) 1996 
  • NIH Study Section on Angiogenesis and Vascular Remodeling (ad hoc) 1996 
  • Swiss National Science Foundation (ad hoc) 1997, 1998 
  • IACUC Committee, 2000-2001 
  • Radiation Safety Committee 200-2002 
  • VA Institutional Review Board, 2000-2001 
  • VA/AMC Steering Committee, 2000-2001

Previous Positions or Appointments

  • Associate Research Biologist, Sterling Winthrop Research Institute, Rensselaer, NY
  • Research Biochemist, Stratton VA Medical Center, Albany, NY
  • Research Assist. Professor of Biochemistry, Albany Medical College, Albany, NY
  • Research Assist. Professor of Medicine, Albany Medical College, Albany, NY
  • Research Scientist, Stratton VA Medical Center, Albany, NY
  • Associate Professor of Medicine, Albany Medical College, Albany, NY
  • Graduate Faculty, Dept. of Physiology, Albany Medical College, Albany, NY
  • Chief, Endothelial Cell Biology Lab, Stratton VA Medical Center, Albany, NY
  • Assoc. Chief of Staff R&D (acting), Stratton VA Medical Center, Albany, NY
  • Asst. Director of Grants, PRI of Albany College of Pharmacy & Health Sciences, Albany, NY
  • Director of Drug Discovery, Vascular Vision Pharmaceuticals, Inc. Rensselaer, NY


Assistant Director, Grants

Pharmaceutical Research Insitute (PRI)

E-mail:  patricia.phillips@acphs.edu
Tel:  (518) 512-3784