Faculty & Staff


Faculty Bios

Assistant Professor

(518) 694-7224
Christopher.Cioffi@acphs.edu

Christopher Cioffi, PH.D.

EDUCATION

  • Ph.D. in Organic Chemistry, Rensselaer Polytechnic Institute, Troy, NY
  • B.S. in Chemistry, Rensselaer Polytechnic Institute, Troy, NY

RESEARCH INTERESTS

  • Medicinal chemistry and small molecule drug discovery
  • Structure- and ligand-based drug design
  • Synthesis of molecular probes for identifying novel targets and elucidating cellular and molecular pharmacology 

SELECTED PUBLICATIONS

Cioffi, C.; Guzzo, P. “Inhibitors of Glycine Transporter-1: Potential Therapeutics for the Treatment of CNS Disorders” Curr. Top. Med. Chem. 2016, in press. DOI:10.2174/1568026616666160405113340.

Cioffi, C.; Racz, B.; Freeman, E.; Conlon, M.; Chen, P.; Stafford, D.; Schwarz, D.; Zhu, L.; Kitchen, D.; Barnes, K.; Dobri, N.; Michelotti, E.; Cywin, C.; Martin, W.; Pearson, P.; Johnson, G.; Petrukhin, K. “Bicyclic [3.3.0]-Octahydrocyclopenta[c]pyrrolo Antagonists of Retinol Binding Protein 4 (RBP4): Potential Treatment of Atrophic Age-Related Macular Degeneration and Stargardt Disease” J. Med. Chem. 2015, 58, 5863.

Cioffi, C.; Dobri, N.; Freeman, E.; Conlon, M.; Chen, P.; Stafford, D.; Schwarz, D.; Golden, K.; Zhu, L.; Kitchen, D.; Barnes, K.; Racz, B.; Qin, Q.; Michelotti, E.; Cywin, C.; Martin, W.; Pearson, P.; Johnson, G.; Petrukhin, K. “Design, Synthesis, and Evaluation of Non-retinoid Retinol Binding Protein 4 Antagonists for the Potential Treatment of Atrophic Age-Related Macular Degeneration and Stargardt Disease” J. Med. Chem. 2014, 57, 7731.

Cioffi, C. "Modulation of NMDA Receptor Function for the Potential Treatment of Schizophrenia" Bioorg. Med. Chem. Lett. 2013, 23, 5034.

Cioffi, C.; Liu, S.; Wolf, M.; Mhyre, A.; Guzzo, P.; Sadalapure, K.; Maeng, J-H.; Parthasarathy, V.; Loong, D.; Carulli, E.; Matta, L.; Anandamma, K.; Choo, S.; Xiao, F.; Swaminathan, V.; Sachdev, N. "Design, Synthesis, and SAR of N-((1-4-(propylsulfonyl)piperazin-1-yl)cycloalkyl)methyl)benzamide Inhibitors of Glycine Transporter-1" Bioorg. Med. Chem. Lett. 2013, 23, 1257.

Manning, D.; Cioffi, C.; Usyatinsky, A.; Fitzpatrick, K.; Masih, L.; Guo, C.; Zhang, Z.; Sikkander, M-I.; Ryan, K.; Naginskaya, J.; Hassler, C.; Dobritsa, S.; Wierschke, J.; Early, W.; Butler, A.; Brady, C.; Barnes, N.; Cohen, M.; Guzzo, P. "Novel Serotonin Type 3 Receptor Partial Agonists for the Potential Treatment of Irritable Bowel Syndrome" Bioorg. Med. Chem. Lett. 2011, 21, 58.

Cioffi, C.; Lansing, J.; Yuksel, H. "Synthesis of 2-Aminobenzoxazoles Using Tetramethylorthocarbonate or 1, 1-Dichlorodiphenoxymethane" J. Org. Chem. 2010, 75, 7942.

Cioffi, C.; Liu, S.; Wolf, M. "Recent Developments in Glycine Transporter-1 Inhibitors" Annual Reports in Medicinal Chemistry 2010, 45, chapter 2, 19.

Cioffi, C.; Spencer, W.; Richards, J.; Herr, R. J. "Generation of 3-Pyridyl Biaryl Systems via Palladium-Catalyzed Suzuki Cross-Couplings of Aryl Halides with 3-Pyridylboroxin" J. Org. Chem. 2004, 69, 2210.

Wentland, M.; Ye, Y.; Cioffi, C.; Lou, R.; Zhou, Q.; Xu. G.; Duan, W.; Denhardt, C.; Sun, X.; Cohen, D.; Bidlack, J. "Synthesis and Opioid Receptor Binding Affinities of 8-Amino-2, 6-methano-3-benzazocines" J. Med. Chem. 2003, 46, 838.

SELECTED POSTER PRESENTATIONS

Moore, N.; Cioffi, C.; Liu, S.; Mhyre, A.; Luche, M.; Guzzo, P.; Rassoulpour, A. Preclinical development of a novel class of competitive inhibitors of the Glycine Transporter-1 (GlyT-1) for the treatment of cognitive deficits. 45th Annual Society for Neuroscience Conference, Chicago, IL, October 17-21, 2015.

Cioffi, C.; Liu, S.; Wolf, M.; Guzzo, P.; Sadalapure, K.; Parthasarathy, V.; Maeng, J-H.; Carulli, E.; Loong, D.; Fang, X.; Gupta, P.; Panduga, S.; Kalesh, K.; Matta, M.; Choo, S.; Buckle, R.; Davis, R.; Sakwa, S.; Hu, M.; Dethe, D.; Decornez, H.; Kitchen, D.; Sargent, B.; Moore, N.; Luche, M.; Khmelnitsky, Y.; Ismail, J.; Adolphson, J.; Padilla, G.; Waikins, K.; Tom, S.; Ngo, A.; Chung, M.; Bai, M.; Johal, N.; Swaminathan, S.; Mhyre, A. “Discovery, SAR, and Biological Evaluation of a Novel Series of Piperazine-Based Inhibitors of Glycine Transporter-1” Abstracts of Papers, 249th ACS National Meeting & Exposition, Denver, CO, US, March 22-26, 2015, MEDI-68.

Manning, D.; Cioffi, C.; Wierscke, J.; Barnes, N.; Moore, N.; Guzzo, P. “The 5-HT3 Partial Agonist ALB-137391(a) for the Treatment of IBS-D” 34th National Medicinal Chemistry Symposium, Charleston, SC, May 18-21, 2014.

Moore, N.; Mhyre, A.; Cioffi, C.; Guzzo, P.; Luche, M.; Liu, S.; Swaminathan, S. “A Novel Series of Competitive GlyT-1 Inhibitors for the Treatment of Schizophrenia” Translation CNS Summit, Boston, MA, May 21-23, 2013.

Mantlo, N.; Cao, G.; Fields, T.; Wang, X.; Chen, X.; Cioffi, C.; Dinn, S.; Fernandez, M-C.; Mateo, A.; Escribano, A.; Martin de la Nava, E.; Parthasarathy, S.; Giese, M.; Carson, M.; Beyer, T.; Cockerham, S.; Kovach, K.; Sweetana, S.; Borel, A.; Jones, T.; Cannady, E. "Discovery and SAR of the Benzazepine Based Chloesteryl Ester Transfer Protein Inhibitor, Evacetrapib" Abstracts of Papers, 243rd ACS National Meeting & Exposition, San Diego, CA, US, March 25-29, 2012, MEDI-235. 

Mhyre, A.; Cioffi, C.; Beebe, A.; Moore, N.; Guzzo, P.; Luche, M.; Sargent, B.; Liu, S. "A Novel Series of GlyT-1 Inhibitors for the Treatment of Schizophrenia: Is Binding Competitively with Glycine Important?" Society for Neuroscience, Washington, DC, November 12-16, 2011.

Cioffi, C.; Liu, S.; Moore, N.; Guzzo, P.; Wolf, M.; Mhyre, A. "AMR-GLY-3, A Novel GLYT-1 Inhibitor for the Treatment of Schizophrenia" NYAS Advancing Drug for Schizoprenia, New York, NY, March 11-12, 2011. 

Manning, D.; Cioffi, C.; Usyantinsky, A.; Fitzpatrick, K.; Masih, L.; Guo, C.; Zhang, Z.; Choo, S.; Sikkander, M-I.; Ryan, K.; Naginskaya, J.; Hassler, C.; Dobritsa, S.; Wierschke, J.; Early, W.; Butler, A.; Brady, C.; Barnes, N.; Cohen, M.; Guzzo. P. “The Discovery of Novel 5-HT3 Receptor Partial Agonists for the Potential Tratment of Irritable Bowel Syndrome“ EFMC-ISMC 2010, 21st International Symposium on Medicinal Chemistry, Brussels, Belgium, September 5-9, 2010.

PATENTS

4-Phenyl Piperidines, Their Preparation and Use, Petrukhin, K.; Cioffi, C.; Johnson, G.; Allikmets, R.; Dobri, N.; Freeman, E.; Conlon, M.; Chen, P.; Zhu, L. PCT Patent Application No. WO 2015168286 A1.

4-Phenyl Piperidines, Their Preparation and Use, Petrukhin, K.; Cioffi, C.; Johnson, G.; Allikmets, R.; Dobri, N.; Freeman, E.; Conlon, M.; Chen, P.; Zhu, L. PCT Patent Application No. WO 2014152013 A1.

Octahydropyrrolopyrroles, Their Preparation and Use, Petrukhin, K.; Cioffi, C.; Johnson, G.; Allikmets, R.; Cywin, C.; Dobri, N.; Freeman, E.; Conlon, M.; Chen, P.; Zhu, L. PCT Patent Application No. WO 2014151936 A1.

N-Alkyl-2-phenoxyethanamines, Their Preparation and Use, Petrukhin, K.; Cioffi, C.; Johnson, G.; Allikmets, R.; Dobri, N.; Freeman, E.; Conlon, M.; Chen, P.; Zhu, L. PCT Patent Application No. WO 2014151959 A1.

Octahydrocyclopentapyrroles, Their Preparation and Use, Petrukhin, K.; Cioffi, C.; Johnson, G.; Allikmets, R.; Dobri, N.; Freeman, E.; Conlon, M.; Chen, P.; Zhu, L. PCT Patent Application No. WO 2014152018 A1.

RBP4 Antagonists for the Treatment of Age-Related Macular Degeneration and Stargardt Disease, Petrukhin, K.; Cioffi, C.; Allikmets, R. US Provisional Application No. 61/785,227.

5-HT3 Receptor Modulators, Methods of Making and Use Thereof, Manning, D.; Cioffi, C., US Patent No. 8710047 B2.

5-HT3 Receptor Modulators, Methods of Making and Use Thereof, Manning, D.; Cioffi, C., US Patent No. 8501729 B2.

5-HT3 Receptor Modulators, Methods of Making and Use Thereof, Manning, D.; Cioffi, C., US Patent No. 8124600 B2.

N-[(Sulfonylpiperazinyl)cycloalkyl]methyl Carboxamide Derivatives as Glycine Transporter-1 Inhibitors and their Preparation, Cioffi, C., Wolf, M.; Guzzo, P.; Sadalapure, K., US Patent No. 9045445 B2.

Synthesis of 2-Aminobenzoxazole Compounds Starting from 2-Aminophenols and Amines, Cioffi, C., US Patent No. 8178666 B2.

Compounds and Methods for Treating Dyslipidemia, Cao, G.; A.; Escribano, A.; Fernandez, M-C.; Fields, T.; Gernert, D.; Cioffi, C.; Herr, R.; Mantlo, N.; Martin de la Nava, E-M.; Mateo-Herranz, A.; Mayhugh, D.; Wang, X. US Patent No. 7749992 B2.

Preparation of Ben[b]azepines and Related Compounds as Inhibitors of Cholesterol Ester Transfer Protein for Treating Dyslipidemia, Chen, X.; Dinn, S.; Cioffi, C.; Escribano, Fernandez, M-C.; Carmen, M.; Fields, T.; Herr, R.; Mantlo, N.; Martin de la Nava, E-M.; Isabel, A.; Partsarathy, S.; Wang, X. US Patent No. 7786108 B2.

PROFESSIONAL ORGANIZATION MEMBERSHIPS

  • American Chemical Society
  • The New York Academy of Science