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Stefan Balaz, Ph.D., D.Sc.
Professor, Chair
Department of Pharmaceutical Sciences, ACPHS-Vermont
Education:
M.S., Slovak University of Technology,
Bratislava, Slovakia
Ph.D. and D.Sc., Comenius University, Bratislava, Slovakia
Selected Recent Publications:
Balaz S: Modeling kinetics of subcellular disposition of chemicals. Chem Rev 2009; 109: 1793-1899.
Zhang Y, Lukacova V, Bartus V, Sun G, Manivannan E, Ghorpade SR, Jin X, Manyem S, Sibi MP, Cook GR and Balaz S: Binding of matrix metalloproteinase inhibitors to extracellular matrix: 3D-QSAR Analysis. Chem Biol Drug Des 2008; 72: 237-248.
Khandelwal A, Balaz S: QM/MM Linear Response method distinguishes ligand binding affinities for closely related metalloproteins. Proteins 2007; 69: 326-339.
Khandelwal A, Balaz, S: Improved estimation of ligand-macromolecule affinities by a Linear Response approach using a combination of multi-mode MD simulation and QM-MM methods, J Comp Aid Mol Des 2007; 21: 131-137.
Zhang Y, Lukacova V, Bartus V, Balaz S: Structural determinants of binding of aromates to ECM: A multi-species multi-mode CoMFA study. Chem Res Toxico/ 2007; 20: 11-19.
Lukacova V, Peng M, Fanucci G, Hinderliter A, Cook GR, Balaz S: Drug-membrane interactions studied in phospholipid monolayers adsorbed on nonporous alkylated microspheres. J Biomol Screen 2007; 12: 186-202.
Lukacova V, Peng M, Tandlich R, Hinderliter A, Balaz S: Partitioning of organic compounds in phases imitating headgroup and core regions of phospholipid bilayers. Langmuir 2006; 22: 1869-1874.
Lukacova V, Zhang Y, Kroll DM, Raha S, Comez D, Balaz S. A comparison of the binding sites of MMPss and TNF-alpha converting enzyme. J Med Chem 2005; 48: 2361-2370.
Khandelwal A, Lukacova V, Kroll OM, Comez 0, Raha S, Balaz S: A combination of docking, QM/MM, and MD simulation for binding affinity estimation of metalloprotein ligands. J Med Chem 2005; 48: 5437 -5447