Dhruba J. Bharali, Ph.D.

Assistant Director of Nanotechnology 
Pharmaceutical Research Institute (PRI)
Tel: (518) 694-7561
Fax: (518) 694-7567
E-mail: Dhruba.Bharali@acphs.edu

Education:

• University of Delhi, Delhi, India M.Sc. 1999, Chemistry
   
  University of Delhi, Delhi, India M. Phil 2000, Chemistry
  
  University of Delhi, Delhi, India Ph.D. 2003, Chemistry (Nanotechnology /Drug Delivery)

Research Interests:

• > Development of biodegradable/biocompatible nanoparticles for biomedical applications
• > Nanoparticles mediated targeted delivery and therapy
• > Nanomaterials based imaging modalities (MRI, Fluorescence imaging)
• > Nanoparticles mediated gene delivery
• > Development of nanotechnology based vaccine formulation

Awards:

• Junior Research Fellow (New Millennium Initiative in Technology and Leadership in India NMITLI) sponsored by Council of Scientific and Industrial Research (CSIR), Government of India, 2001-2003

Selected Publications:

• Dhruba Jyoti Bharali, Sanjeeb Kumar Sahoo, Subho Mozumdar and Amarnath Maitra; Cross-Linked Polyvinylpyrrolidone Nanoparticles: A Potential Carrier for Hydrophilic Drugs. Journal of Colloid and Interface Science, 2003, 258(2), 415-423.
  
  Dhruba J.  Bharali, Derrick W. Lucey, Harishankar Jayakumar, Haridas E. Pudavar, Paras N Prasad, Folate-Receptor-Mediated Delivery of InP Quantum Dots for Bioimaging Using Confocal and Two-Photon Microscopy, Journal of the American Chemical Society, 2005, 127(32),  11364-1137.
  
  Indrajit Roy, Tymish Y. Ohulchanskyy, Dhruba J. Bharali, Haridas E. Pudavar  Ruth A. Mistretta, Navjot Kaur, Paras N. Prasad, Optical tracking of organically modified silica nanoparticles as DNA carriers: A non-viral, nanomedicine approach for gene delivery, Proceedings of the National Academy of Sciences of the United States of America (PNAS), 2005, January 11, 102(2), 279-284.
  
  Dhruba J. Bharali, Ilona Klejbor,  Ewa K. Stachowiak,.Purnendu Dutta, Indrajit Roy, Navjot Kaur, Earl J. Bergey,  Paras N. Prasad, Michal K. Stachowiak, Organically modified silica nanoparticles: A nonviral vector for in vivo gene delivery and expression in the brain, Proceedings of the National Academy of Sciences of the United States of America (PNAS), 2005, August 9, 102 ( 32), 11539–11544.
  
  Sehoon Kim, Qingdong Zheng, Guang S. He, Dhruba J. Bharali, Haridas E. Pudavar, Alexander Baev, and Paras N. Prasad,  Aggregation-Enhanced Fluorescence and Two-Photon Absorption in Nanoaggregates of a 9,10-Bis[4 -(4 -aminostyryl)styryl]anthracene Derivative, Advanced Functional Materials, 2006, 16, 2317-232.
  
  I. Klejbor, E.K. Stachowiak, D. J. Bharali, I. Roy, I. Spodnik, J. Morys, E. J.  Bergey, P.N Prasad, and M.K. Stachowiak, ORMOSIL Nanoparticles as a Non-Viral Gene Delivery Vector for modeling Polyglutamine induced Brain Pathology. Journal of Neuroscience Methods 2007, 165(2):230-243.
  
  Dhruba J Bharali, Vandana Pradhan, Galina Elkin, Galina Elkin, Wu Qi, Alan Hutson, Shaker A. Mousa, Yasmin Thanavala. Novel nanoparticles for the delivery of recombinant hepatitis B vaccine. Nanomedicine. 2008, (4):311-7. Epub 2008 Jul 18.
  
  Imtiaz A Siddiqui, Vaqar M Adhami, Dhruba J Bharali, Bilal B Hafeez, Mohammad Asim, Sabih I Khwaja, Nihal Ahmad, Huadong Cui, Shaker A Mousa, Hasan Mukhtar. Introducing nanochemoprevention as a novel approach for cancer control: proof of principle with green tea polyphenol epigallocatechin-3-gallate. Cancer Research. 2009, 69(5):1712-6. Epub 2009 Feb 17.
  
  Yalcin M, Bharali DJ, Lansing L, Dyskin E, Mousa SS, Hercbergs A, Davis FB, Davis PJ, Mousa SA. Tetraidothyroacetic acid (tetrac) and tetrac nanoparticles inhibit growth of human renal cell carcinoma xenografts. Anticancer Res. 2009 Oct;29(10):3825-31.
  
  Dhruba J Bharali, Usawadee Dier, Paul J.  Davis, Shaker A. Mousa. Tetrac-Conjugated Quantum Dots for Diagnosis and Treatment of Pancreatic Cancer: An In Vitro Evaluation, Immunology, Endocrine & Metabolic Agents - Medicinal Chemistry, Volume 9, Number 4, December 2009, pp. 219-223.
  
  Yalcin M, Bharali DJ, Dyskin E, Dier E, Lansing L, Mousa SS, Davis FB, Davis, PJ, Mousa SA. Tetraiodothyroacetic Acid and tetraiodothyroacetic Acid nanoparticle effectively inhibit the growth of human follicular thyroid cell carcinoma. Thyroid. 2010 Mar;20(3):281-6.
  
  Yalcin M, Dyskin E, Lansing L, Bharali DJ, Mousa SS, Bridoux A, Hercbergs AH, Lin HY, Davis FB, Glinsky GV, Glinskii A, Ma J, Davis PJ, Mousa SA. Tetraiodothyroacetic Acid (Tetrac) and Nanoparticulate Tetrac Arrest Growth of Medullary Carcinoma of the Thyroid. J Clin Endocrinol Metab.  2010 Apr;95(4):1972-80. Epub 2010 Feb 4.
  
  Shaker A. Mousa, Murat Yalcin, Dhruba J Bharali, Ran Meng, Heng-Yuan Tang, Hung-Yun Lin, Faith B. Davis, Paul J. Davis, Tetraiodothyroacetic Acid and its Nanoformulation Inhibit Thyroid Hormone Stimulation of Non-Small Cell Lung Cancer Cells in vitro and its Growth in Xenografts, Lung Cancer, 2011.
  
  Shaker A Mousa, Dhruba J Bharali, Nanotechnology-based detection and targeted therapy in cancer: nano-bio paradigms and applications, Cancers 2011, 3, 2888-2903.
  
  Melamangalam S. Jayaraman, Dhruba J. Bharali, Thangirala Sudha, Shaker A. Mousa, Nano Chitosan Peptide As A Potential Therapeutic Carrier For Retinal Delivery To Treat Age-Related Macular Degeneration,  2012, Molecular Vision 2012;18:2300-8. Epub 2012 Sep 3.
  
  Dhruba J. Bharali, Murat Yalcin, Paul J. Davis, Shaker A. Mousa. Tetraiodothyroacetic acid (Tetrac) conjugated PLGA nanoparticles: A nanomedicine approach to treat drug-resistant breast cancer submitted to Nanomedicine (future medicine) 2013, in press. 

Book:

• Oxidative Stress and Nanotechnology: Methods and Protocols. Edited by Donald Armstrong and Dhruba J. Bharali; Springer, NY, USA; 2013, in press.

Book Chapters (selected):

• Susmita Mitra, Dhruba Jyoti Bharali, Amarnath Maitra, Hydrogel Nanoparticles synthesized of Cross-Linked Polyvinylpyrrolidone , Encyclopaedia of Nanoscience and Nanotechnology, Marcel Dekker Inc, edited by Schwarz, J. A., Contescu, C., Putyera K. , 2004, 1403-1414.
  
  Dhruba J Bharali, Shaker A Mousa, Yasmin Thanavala.  Micro- and nanoparticle-based vaccines for hepatitis B, Immune-Mediated Diseases: from theory to therapy, Springer, edited by Shurin, M. R. and Smolkin, Y.S. , 2007, pp 415-21.
  
  Hung-Yun Lin, Faith B. Davis, Mary K. Luidens, Aleck Hercbergs Shaker A. Mousa, Dhruba J. Bharali and Paul J. Davis Newly-Recognized Small Molecule Receptors on Human Breast Cancer Cell Integrin avß3 that Affect Tumor Cell Behavior ;  Targeting New Pathways and Cell Death in Breast Cancer: Edited by Rebecca L. Aft ;  Publisher: InTech, , 2012, pp 85-96

Patents Submitted:

• Paras N. Prasad, Michal K. Stachowiak, Earl J. Bergey, Purnendu Dutta,  Dhruba J. Bharali, Ilona Klejbor, Tymish Ohulchanskyy , Indrajit Roy, Amino Functionalized ORMOSIL Nanoparticles as delivery vehicles, USA Patent application No. 20060088599 A1, ( 2006).
  
  Paras N. Prasad, Richard Mazurchuk, Dhruba J. Bharali, Dinesh K. Sukumaran, Earl J Bergey, Joseph Spernyak,  Mukund Seshadri, Hybird Inorganic Nanoparticles, Methods of Using and Methods of Making. USA Patent application No 20060222587 A1, (2006)

Patent:

• Amarnath  Maitra, Subho Mozumdar, Susmita Mitra and Dhruba Jyoti Bharali; A Process for the preparation Of pH sensitive, mucoadhesive smart hydrogel nanoparticles as potential carriers for systemic delivery of water soluble drugs through oral route,  Indian Patent No. 217609.

Research and Conference Presentations (selected):

• Dhruba J Bharali, Dalia Chattopadhyay, Subho Mozumdar,  Amarnath Maitra, Cross-Linked Polyvinylpyrrolidone Nanoparticles as Non-Viral Vectors for In Vitro and In Vivo Delivery of Genes. Proceedings of the 30th Annual Meeting and Exposition of the Controlled Release Society; July 19–23 2003; 579, Glasgow, Scotland, U.K.
  
  Shaker A. Mousa, Dhruba J Bharali, Lubor Borsig, Emmy Dier, Shaymaa S. Mousa, Murat Yalcin, and Patricia Phillips. Site-directed therapy with non-anticoagulant heparins and chemotherapy in breast cancer. 5th Era of Hope Meeting (Department of Defense Program), June 25-28, 2008,  Baltimore Convention Center , Baltimore, Maryland, USA.
  
  Dhruba J Bharali, Usawadee Dier, Tessa M Simone, Shaker A Mousa, Biodegradable Nanoparticles Encapsulating Paclitaxel: A Potential Platform for Site-specific Therapy and Imaging of ovarian cancer,  Pharmaceutical Sciences World Congress 2010, 14-18 November 2010,   Morial Convention Center , New Orleans, Louisiana, USA.
  
  Dhruba J. Bharali,  Nanotechnology and Cancer Imaging & Treatment, The 2011 Annual Meeting of the AAPS Northeast Regional Discussion Group (NERDG) , April 15, 2011 at the Marriott Hotel in Rocky Hill, CT, USA.

Previous Positions or Appointments:

• > Postdoctoral Associate, Institute for Laser Photonics and Biophotonics, SUNY at Buffalo, Buffalo, NY
• > Postdoctoral Fellow, Department of Immunology, Roswell Park Cancer Institute, Buffalo, NY
• > Senior Nanotechnology Scientist, Pharmaceutical Research Institute, Albany College of Pharmacy and Health Sciences, Rensselaer, NY