Arnold Johnson, Ph.D.
Department of Pharmaceutical Sciences, Albany Campus
Tel: (518) 694-7128
- Ph.D., Albany Medical College, Albany, NY
Courses Taught at ACPHS:
- > Pharmacology/Medicinal Chemistry II
- > Journal Club
- > Seminar I
- > Seminar II
- > Topics in Medicine: Inflammatory Diseases
- > Topics in Medicine: Lung Injury
- Dr. Johnson's primary research interest is the study of inflammation-mediated organ dysfunction. His research focuses on the pathogenesis of pulmonary edema, a major cause of death and disability during systemic inflammation and septic shock. Specifically, Dr. Johnson investigates the role of the cytokine, tumor necrosis factor-a, in the pathogenesis of pulmonary edema and lung dysfunction. The effect of tumor necrosis factor-a on the lung endothelial cell cytoskeleton, protein kinase C, glycogen synthetase3 b, and reactive oxygen and nitrogen molecules is a focus in Dr. Johnson's laboratory. Recently, an additional focus in Dr. Johnson's laboratory is elucidating the pathways that link TNF-induced inflammation with neoplasia. An improved understanding of the molecular mechanisms that cause inflammation mediated organ dysfunction will ultimately lead to better treatments for septic shock and other disorders such as cancer.
- In 2010, Dr. Johnson was awarded a four year grant from the National Institutes of Health in the amount of $1.4 million to study lung inflammation associated with septic shock.
- Neumann, P.H., N. Gertzberg, E. Vaughan, J. Weisbrot, R. Woodburn, W. Lambert and A. Johnson. Peroxynitrite mediates TNF-? induced endothelial barrier dysfunction and nitration of actin. Am. J. Physiol. 290: L674-L684, 2006.
Gertzberg, N., T. Gurnani, P. Neumann, A. K. Forbes, N. J. Louis and A. Johnson. Tumor necrosis factor-? (TNF) causes barrier dysfunction mediated by tyrosine198 & tyrosine218 in ?-actin. Am. J. Physiol. 293: L1219-L1229, 2007.
Johnson, A. TNF induced activation of pulmonary microvessel endothelial cells: a role for GSK3ß. Am. J. Physiol, 2009.