Alexandre A. Steiner, Pharm.D., Ph.D.
Department of Pharmaceutical Sciences, Albany Campus
Tel: (518) 694-7154
- Ph.D., Medical School of Ribeirao Preto, University of Sao Paulo, Brazil
Pharm.D., Pharmacy School of Ribeirao Preto, University of Sao Paulo, Brazil
Courses Taught at ACPHS:
- > Pathophysiology
- > Therapeutics
- > Pharmacology and medicinal chemistry of cardiovascular disorders
- > Graduate pharmacology III
- Dr. Steiner studies the physiological strategies employed by the body to cope with systemic inflammation and infection. These host-defense strategies can be divided into two major categories. In one category are those strategies that are aimed at actively fighting infection using the body’s energy reserves; fever is the most typical example of such strategies. In the other category are those strategies that are aimed at conserving the body’s precious energy reserves; typical examples include hypothermia and behavioral depression. What are the internal and environmental clues that determine which of these completely distinct strategies is used? How does the body interpret these clues at molecular, cellular, and systemic levels? Does the body ever fail to select the most appropriate strategy? If so, are there therapeutic ways to correct for such a failure? These and other questions are currently the focus of research in Dr. Steiner’s laboratory.
- Dr. Steiner serves on the Editorial Review Board of The American Journal of Physiology: Regulatory Integrative and Comparative Physiology. AJP is the leading journal in the field of experimental physiology.
- Krall CM, Yao X, Hass MA, Feleder C, Steiner AA. Food deprivation alters thermoregulatory responses to lipopolysaccharide by enhancing cryogenic inflammatory signaling via prostaglandin D2. Am J Physiol Regul Integr Comp Physiol 298: R1512-R1521, 2010.
Steiner AA, Hunter JC, Phipps SM, Nucci TB, Oliveira DL, Roberts JL, Scheck AC, Simmons DL, Romanovsky AA. Cyclooxygenase-1 or -2: which one mediates lipopolysaccharide-induced hypothermia? Am J Physiol Regul Integr Comp Physiol 297: R485-R494, 2009.
Steiner AA, Krall CM, Liu E. A reappraisal on the ability of leptin to induce fever. Physiol Behav 97: 430-436, 2009 Steiner AA, Turek VF, Almeida MC, Burmeister JJ, Oliveira DL, Roberts JL, Bannon AW, Norman MH, Louis JC, Treanor JJ, Gavva NR, Romanovsky AA. Nonthermal activation of transient receptor potential vanilloid-1 channels in abdominal viscera tonically inhibits autonomic cold-defense effectors. Journal of Neuroscience 27: 7459-7468, 2007.
Steiner AA and Romanovsky AA. Leptin: at the crossroads of energy balance and systemic inflammation. Progress in Lipid Research 46: 89-107, 2007.
Steiner AA, Ivanov AI, Serrats J, Hosokawa H, Phayre AN, Robbins JR, Roberts JL, Kobayashi S, Matsumura K, Sawchenko PE, Romanovsky AA. Cellular and molecular bases of the initiation of fever. PLoS Biology 4: e284, 2006.